The multifaceted roles of perlecan in fibrosis

被引：39
作者：
Lord, Megan S. [1 ]
Tang, Fengying [1 ]
Rnjak-Kovacina, Jelena [1 ]
Smith, James G. W. [2 ]
Melrose, James [1 ,3 ,4 ]
Whitelock, John M. [1 ]
机构：
[1] UNSW Sydney, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia
[2] Univ Nottingham, Nottingham NG7 2RD, England
[3] Kolling Inst Northern Sydney Local Hlth Dist, Raymond Purves Bone & Joint Res Lab, St Leonards, NSW 2065, Australia
[4] Univ Sydney, Royal North Shore Hosp, Sydney Med Sch, St Leonards, NSW 2065, Australia
来源：
MATRIX BIOLOGY | 2018年 / 68-69卷
基金：
澳大利亚研究理事会;
关键词：
Fibrosis; Proteoglycan; Perlecan; Heparan sulfate; SMOOTH-MUSCLE-CELLS; HEPARAN-SULFATE PROTEOGLYCANS; FIBROBLAST-GROWTH-FACTOR; IDIOPATHIC PULMONARY-FIBROSIS; HEPATIC STELLATE CELLS; EXTRACELLULAR-MATRIX PROTEINS; HUMAN LUNG FIBROBLASTS; BASEMENT-MEMBRANE; ENDOTHELIAL-CELLS; GENE-EXPRESSION;
D O I：
10.1016/j.matbio.2018.02.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a temporal and dynamic fashion. In this review, its roles in fibrosis are reviewed by drawing upon evidence from tissue and organ systems that undergo fibrosis as a result of an uncontrolled response to either inflammation or traumatic cellular injury leading to an over production of a collagen-rich extracellular matrix. This review focuses on examples of fibrosis that occurs in lung, liver, kidney, skin, kidney, neural tissues and blood vessels and its link to the expression of perlecan in that particular organ system. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：150 / 166
页数：17
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