New and emerging therapies for systemic lupus erythematosus

被引：1

作者：

Papachristodoulou, Eleni ^{[1
]}

Kyttaris, Vasileios C. ^{[1
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Rheumatol, 110 Francis St,Suite 4B, Boston, MA 02215 USA

来源：

CLINICAL IMMUNOLOGY | 2024年 / 263卷

关键词：

Systemic lupus erythematosus; Treatment; BLyS; Interferon; B cells; MESENCHYMAL STEM-CELL; PLACEBO-CONTROLLED TRIAL; RANDOMIZED DOUBLE-BLIND; REGULATORY T-CELLS; MYCOPHENOLATE-MOFETIL; MONOCLONAL-ANTIBODY; DISEASE-ACTIVITY; B-CELL; RHEUMATOID-ARTHRITIS; N-ACETYLCYSTEINE;

D O I：

10.1016/j.clim.2024.110200

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic Lupus Erythematosus (SLE) and lupus nephritis treatment is still based on non-specific immune suppression despite the first biological therapy for the disease having been approved more than a decade ago. Intense basic and translational research has uncovered a multitude of pathways that are actively being evaluated as treatment targets in SLE and lupus nephritis, with two new medications receiving FDA approval in the last 3 years. Herein we provide an overview of targeted therapies for SLE including medications targeting the B lymphocyte compartment, intracellular signaling, co-stimulation, and finally the interferons and other cytokines.

引用

页数：20

共 236 条

[71] Safety, efficacy and pharmacokinetics of low-dose telitacicept in an elderly immunocompromised patient with systemic lupus erythematosus [J].

Guan, Xin ;

Zhao, Zerui ;

Xia, Guangtao ;

Xin, Miaomiao ;

Yang, Qingrui ;

Sun, Hongling ;

Fu, Min .

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2023, 26 (07) :1399-1402

[72]

Gupta R., 2022, Arthritis Rheumatol, V74

[73] Ofatumumab treatment in lupus nephritis patients [J].

Haarhaus, Malena Loberg ;

Svenungsson, Elisabet ;

Gunnarsson, Iva .

CLINICAL KIDNEY JOURNAL, 2016, 9 (04) :552-555

[74] Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration [J].

Harada, Tatsuhiro ;

Kyttaris, Vasileios ;

Li, Yansong ;

Juang, Yuang-Taung ;

Wang, Ying ;

Tsokos, George C. .

AUTOIMMUNITY, 2007, 40 (01) :1-8

[75] Safety and Tolerability of Omalizumab: A Randomized Clinical Trial of Humanized Anti-IgE Monoclonal Antibody in Systemic Lupus Erythematosus [J].

Hasni, Sarfaraz ;

Gupta, Sarthak ;

Davis, Michael ;

Poncio, Elaine ;

Temesgen-Oyelakin, Yenealem ;

Joyal, Elizabeth ;

Fike, Alice ;

Manna, Zerai ;

Auh, Sungyoung ;

Shi, Yinghui ;

Chan, Diana ;

Carlucci, Philip ;

Biehl, Ann ;

Dema, Barbara ;

Charles, Nicolas ;

Balow, James E. ;

Waldman, Meryl ;

Siegel, Richard M. ;

Kaplan, Mariana J. ;

Rivera, Juan .

ARTHRITIS & RHEUMATOLOGY, 2019, 71 (07) :1135-1140

[76] Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus [J].

Hasni, Sarfaraz A. ;

Gupta, Sarthak ;

Davis, Michael ;

Poncio, Elaine ;

Temesgen-Oyelakin, Yenealem ;

Carlucci, Philip M. ;

Wang, Xinghao ;

Naqi, Mohammad ;

Playford, Martin P. ;

Goel, Rishi R. ;

Li, Xiaobai ;

Biehl, Ann J. ;

Ochoa-Navas, Isabel ;

Manna, Zerai ;

Shi, Yinghui ;

Thomas, Donald ;

Chen, Jinguo ;

Biancotto, Angelique ;

Apps, Richard ;

Cheung, Foo ;

Kotliarov, Yuri ;

Babyak, Ashley L. ;

Zhou, Huizhi ;

Shi, Rongye ;

Stagliano, Katie ;

Tsai, Wanxia Li ;

Vian, Laura ;

Gazaniga, Nathalia ;

Giudice, Valentina ;

Lu, Shajia ;

Brooks, Stephen R. ;

MacKay, Meggan ;

Gregersen, Peter ;

Mehta, Nehal N. ;

Remaley, Alan T. ;

Diamond, Betty ;

O'Shea, John J. ;

Gadina, Massimo ;

Kaplan, Mariana J. .

NATURE COMMUNICATIONS, 2021, 12 (01)

[77] Efficacy of bortezomib in reduction of systemic lupus erythematosus disease activity index score: A meta-analysis [J].

He, Huan ;

Luo, Man ;

Xiong, Jin-He .

EUROPEAN JOURNAL OF INFLAMMATION, 2022, 20

[78] Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial [J].

He, Jing ;

Zhang, Ruijun ;

Shao, Miao ;

Zhao, Xiaozhen ;

Miao, Miao ;

Chen, Jiali ;

Liu, Jiajia ;

Zhang, Xiaoying ;

Zhang, Xia ;

Jin, Yuebo ;

Wang, Yu ;

Zhang, Shilei ;

Zhu, Lei ;

Jacob, Alexander ;

Jia, Rulin ;

You, Xujie ;

Li, Xue ;

Li, Chun ;

Zhou, Yunshan ;

Yang, Yue ;

Ye, Hua ;

Liu, Yanying ;

Su, Yin ;

Shen, Nan ;

Alexander, Jessy ;

Guo, Jianping ;

Ambrus, Julian ;

Lin, Xin ;

Yu, Di ;

Sun, Xiaolin ;

Li, Zhanguo .

ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 (01) :141-149

[79] Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus [J].

He, Jing ;

Zhang, Xia ;

Wei, Yunbo ;

Sun, Xiaolin ;

Chen, Yaping ;

Deng, Jun ;

Jin, Yuebo ;

Gan, Yuzhou ;

Hu, Xin ;

Jia, Rulin ;

Xu, Chuanhui ;

Hou, Zhaohua ;

Leong, Yew Ann ;

Zhu, Lei ;

Feng, Jinhong ;

An, Yuan ;

Jia, Yuan ;

Li, Chun ;

Liu, Xu ;

Ye, Hua ;

Ren, Limin ;

Li, Ru ;

Yao, Haihong ;

Li, Yuhui ;

Chen, Shi ;

Zhang, Xuewu ;

Su, Yin ;

Guo, Jianping ;

Shen, Nan ;

Morand, Eric F. ;

Yu, Di ;

Li, Zhanguo .

NATURE MEDICINE, 2016, 22 (09) :991-+

[80] First use of cenerimod, a selective S1P1 receptor modulator, for the treatment of SLE: a double-blind, randomised, placebo-controlled, proof-of-concept study [J].

Hermann, Viktoria ;

Batalov, Anastas ;

Smakotina, Svetlana ;

Juif, Pierre-Eric ;

Cornelisse, Peter .

LUPUS SCIENCE & MEDICINE, 2019, 6 (01)

← 3 4 5 6 7 8 9 10 11 12 →