Environmental exposure to metal(loid)s and hypertensive disorders of pregnancy: A systematic review

被引:3
作者
de Melo, Nayra Carla [1 ,2 ]
Souza, Priscilla Cristovam Sampaio e [1 ]
Marques, Rejane Correa [3 ]
Bernardi, Jose Vicente Elias [4 ]
Bastos, Wanderley Rodrigues [1 ,2 ]
Cunha, Monica Pereira Lima [1 ,2 ]
机构
[1] Fed Univ Rondonia Fdn, Postgrad Program Reg Dev & Environm, BR-76801059 Porto Velho, Rondonia, Brazil
[2] Fed Univ Rondonia Fdn, WCP Environm Biogeochem Lab, BR-76801058 Porto Velho, Rondonia, Brazil
[3] Fed Univ Rio De Janeiro Janeiro UFRJ, Postgrad Program Environm Sci & Conservat, BR-27965045 Macae, RJ, Brazil
[4] Univ Brasilia, UnB Planaltina Coll, Geostat & Geodesy Lab, BR-73345010 Planaltina, DF, Brazil
关键词
Metals; Heavy metals; Trace elements; Environmental exposure; Hypertension; Pregnancy; -induced; Preeclampsia; BLOOD LEAD; CARDIOVASCULAR-DISEASE; HEART-DISEASE; MERCURY; PREECLAMPSIA; WOMEN; CADMIUM; ASSOCIATION; MORTALITY; STRONTIUM;
D O I
10.1016/j.envres.2024.119391
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Environmental exposure to metal(loid)s has been associated with adverse effects on human health, but the systemic repercussion of these elements on the development of hypertensive disorders of pregnancy (HDP) is still poorly understood. Objective: To summarize evidence published about the influence of environmental exposure to aluminum, arsenic, barium, cadmium, lead, strontium and mercury on the development of HDP. Methods: We conducted a systematic literature review according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The search strategy was validated by the Peer Review of Electronic Search Strategies. We searched for articles published up to February 2023 in seven databases without language restriction. Two researchers conducted the steps for selection, data extraction and evaluation of the methodological quality of the instruments for epidemiological studies of the Joanna Briggs Institute. Any disagreements were resolved by a third researcher. Results: We obtained 5076 records, of which 37 articles met the inclusion criteria moderate to high methodological quality. Single exposure to metal(loid)s was predominant, and the leading biological matrix analyzed to detect the concentrations from exposure was maternal blood. Lead was the metal investigated the most, and had the largest number of studies showing positive association with HDP. In relation to the other metal(loid)s, higher levels were found in women with HDP in comparison with healthy women, but the finding of a cause-effect relationship was inconsistent. Conclusions: Although we found evidence of harmful effects of the metal(loid)s studied on human health, the results were inconclusive with regard to HDP. Longitudinal studies that consider prospective investigation, adjustment of confounding factors and the interference of other contaminants in the exacerbation of oxidative stress in women from the preconception phase to the puerperal period should be encouraged.
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页数:14
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