Serum YKL-40 Levels and Chitotriosidase Activity in Patients with Beta-Thalassemia Major

被引:6
作者
Musumeci, Maria [1 ]
Caruso, Vincenzo [2 ]
Medulla, Emilia [2 ]
Torrisi, Venerando [3 ]
Migale, Roberta [4 ]
Angeletti, Silvia [1 ]
Musumeci, Salvatore [5 ,6 ]
机构
[1] Univ Rome, Dept Lab Med & Microbiol, Ctr Integrated Res, I-00128 Rome, Italy
[2] Ctr Microcitemia, I-95123 Catania, Italy
[3] IRMA, I-95024 Acireale, Catania, Italy
[4] Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, Parturit Res Grp, Dept Surg & Canc, London W12 0NN, England
[5] Univ Catania, Dept Chem Sci, I-95125 Catania, Italy
[6] CNR, Inst Biomol Chem, I-95125 Catania, Italy
关键词
RHEUMATOID-ARTHRITIS; HEPATITIS-C; MARKER; FIBROSIS; EXPRESSION; BIOMARKER; PROTEIN; CHI3L1; GENE; MACROPHAGES;
D O I
10.1155/2014/965971
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background. YKL-40 association with human disease has been the object of many years of investigation. beta-thalassemia patients are affected by hepatic siderosis, which determines a fibrotic process and tissue remodelling. Chitotriosidase has been found to be increased in thalassemic patients returning to normal in patients submitted to bone marrow transplantation. YKL-40 is associated with macrophage activation in liver and in other tissues. The aim of the study was to analyse the level of serum YKL-40 and plasma chitotriosidase activity of patients with beta-thalassemia to assess whether their expression correlates with liver disease and degree of liver siderosis. Methods. Expression of YKL-40 and chitotriosidase as a marker of inflammation in 69 thalassemic patients were evaluated. We sought to investigate whether these two chitinases could be considered as a significant biomarker to evaluate therapy effectiveness. Results. Surprisingly we found normal value of YKL-40. We, also, analysed chitotriosidase activity in the same patients that was slightly increased as a consequence of macrophage activation. Conclusions. These data would suggest a good treatment for these patients.
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页数:6
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