Immunotherapy Using Activated Natural Killer Cells Improves Postoperative Neutrophil-to-Lymphocyte Ratio and Long-Term Prognosis of Living Donor Liver Transplant Recipients With Hepatocellular Carcinoma

被引：0

作者：

Imaoka, Kouki ^{[1
]}

Ohira, Masahiro ^{[1
,2
]}

Hattori, Minoru ^{[3
]}

Chogahara, Ichiya ^{[1
]}

Sato, Saki ^{[1
]}

Nakamura, Mayuna ^{[1
]}

Bekki, Tomoaki ^{[1
]}

Sato, Koki ^{[1
]}

Imaoka, Yuki ^{[1
]}

Nakano, Ryosuke ^{[1
]}

Yano, Takuya ^{[1
]}

Sakai, Hiroshi ^{[1
]}

Kuroda, Shintaro ^{[1
]}

Tahara, Hiroyuki ^{[1
]}

Ide, Kentaro ^{[1
]}

Kobayashi, Tsuyoshi ^{[1
]}

Tanaka, Yuka ^{[1
]}

Ohdan, Hideki ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Gastroenterol & Transplant Surg, 1-2-3 Kasumi,Minami Ku, Hiroshima 7348551, Japan

[2] Hiroshima Univ Hosp, Med Ctr Translat & Clin Res, Div Regenerat & Med, Hiroshima, Japan

[3] Hiroshima Univ, Inst Biomed & Hlth Sci, Adv Med Skills Training Ctr, Hiroshima, Japan

来源：

TRANSPLANTATION PROCEEDINGS | 2024年 / 56卷 / 03期

关键词：

NK CELLS; APOPTOSIS; PREDICTS;

D O I：

10.1016/j.transproceed.2024.02.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective. Preoperative neutrophil-to-lymphocyte ratio (NLR) is a well-known prognostic indicator in various malignancies; however, the impact of postoperative NLR on living donor liver transplant (LDLT) recipients is unknown. Immunotherapy with donor liver-derived activated natural killer (NK) cells may improve postoperative NLR by coactivating immune cells or suppressing activated neutrophils. This study aims to clarify the clinical significance of postoperative NLR in recipients after LDLT with HCC and assess whether immunotherapy improves postoperative NLR. Methods. We conducted a retrospective study of LDLT recipients between 2001 and 2022 to evaluate the clinical significance of postoperative NLR. Furthermore, the correlation between postoperative NLR and the activation marker of infused NK cells was also evaluated. The postoperative NLR was examined 4 weeks after LDLT. Results. The postoperative high NLR group (N = 78) had preoperative lower NLR and higher model for end-stage liver disease and a higher rate of postoperative infection within 30 days after LDLT than the postoperative low NLR group (N = 41). Postoperative high NLR (hazard ratio [HR], 2.62; 95% confidence interval [CI], 1.01-6.79; P = .047) and nontreatment of immunotherapy (HR, 3.10; 95% CI, 1.33-7.22; P < .01) were independent risk factors for poor overall survival in multivariate analysis. Furthermore, the activation marker of infused NK cells is inversely correlated with decreased postoperative NLR. Conclusions. The higher level of postoperative NLR was independently associated with poor prognosis in patients after LDLT with HCC. Immunotherapy using activated NK cells may improve postoperative NLR and long-term prognosis.

引用

页码：634 / 639

页数：6

共 27 条

[1] Downregulation of HLA Class I Renders Inflammatory Neutrophils More Susceptible to NK Cell-Induced Apoptosis [J].