Successful phage-antibiotic therapy of P. aeruginosa implant-associated infection in a Siamese cat

被引:5
|
作者
Braunstein, Ron [1 ]
Hubanic, Goran [2 ]
Yerushalmy, Ortal [1 ]
Oren-Alkalay, Sivan [1 ]
Rimon, Amit [1 ,3 ]
Coppenhagen-Glazer, Shunit [1 ]
Niv, Ofir [2 ]
Marom, Hilik [2 ]
Barsheshet, Alin [2 ]
Hazan, Ronen [1 ,4 ]
机构
[1] Hebrew Univ Jerusalem, Inst Biomed & Oral Res IBOR, Fac Dent Med, Jerusalem, Israel
[2] Anim Med Ctr, Vet Holim, Kiryat Anavim, Israel
[3] Hebrew Univ Jerusalem, Hadassah Med Sch, Tzameret, Mil Track Med, Jerusalem, Israel
[4] Hebrew Univ Jerusalem, Fac Dent Med, Campus POB 12272, IL-91120 Jerusalem, Israel
关键词
Bacteriophage; phage therapy; pseudomonas aeruginosa; antibiotic resistance; implant-associated infection; BACTERIOPHAGES; DOGS;
D O I
10.1080/01652176.2024.2350661
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Antibiotic-resistant pathogens are a growing global issue, leading to untreatable infectious diseases in both humans and animals. Personalized bacteriophage (phage) therapy, the use of specific anti-bacterial viruses, is currently a leading approach to combat antibiotic-resistant infections. The implementation of phage therapy has primarily been focused on humans, almost neglecting the impact of such infections on the health and welfare of companion animals. Pets also have the potential to spread resistant infections to their owners or the veterinary staff through zoonotic transmission. Here, we showcase personalized phage-antibiotic treatment of a cat with a multidrug-resistant Pseudomonas aeruginosa implant-associated infection post-arthrodesis surgery. The treatment encompassed a tailored combination of an anti-P. aeruginosa phage and ceftazidime, precisely matched to the pathogen. The phage was topically applied to the surgical wound while the antibiotic was administered intramuscularly. After two treatment courses spanning 7 and 3 weeks, the surgical wound, which had previously remained open for five months, fully closed. To the best of our knowledge, this is the first case of personalized phage therapy application in felines, which provides further evidence of the effectiveness of this approach. The successful outcome paves the way for personalized phage-antibiotic treatments against persistent infections therapy in veterinary practice.
引用
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页码:1 / 9
页数:9
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