Predictors of patient response to cystourethroscopy with hydrodistention for interstitial cystitis/bladder pain syndrome: Does BMI matter?

Objective: To compare therapeutic outcomes of cystourethroscopy with hydrodistention for interstitial cystitis in underweight, overweight, and obese women. Methods: We conducted a 10 -year (2008-2018), single -site retrospective cohort study of female patients with a diagnosis of IC/BPS and who had undergone hydrodistention for primary diagnosis of IC/PBS. Our primary outcome was a binary indicator of patient -reported improvement after hydrodistention. Our primary exposure was patient BMI. Baseline demographic characteristics, operative information, and follow-up data were collected by performing medical chart reviews. Descriptive statistics were used to assess improvement across various patient and operative characteristics. Log -binomial regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) representing the association between BMI and other factors and symptom improvement after cystourethroscopy with hydrodistention. Results: Seventy-two women met the inclusion criteria. Of those, 54 (75%) reported improvement of their IC/BPS symptoms after the procedure. We did not observe statistically significant differences in improvement across levels of BMI categories. Patients with a history of hydrodistention were 1.3 times as likely to have improvement (95% CI: 1.01, 1.62) and those reporting cigarette smoking or history of smoking were 33% less likely to report improvement (RR: 0.67, 95% CI: 0.45-0.99). Conclusion: There was no association between BMI and therapeutic response to hydrodistention in patients with IC/BPS. This may help aiding in future counseling for patient with IC/BPS and their treatment options and expectations. Brief Summary: This study is a 10 -year, retrospective cohort study of female patients evaluating the association between BMI and therapeutic response to hydrodistension in patient with IC/BPS.