Blastic plasmacytoid dendritic cell neoplasm (BPDCN) arising in the setting of polycythemia vera (PV): An illustration of the emerging role of flow cytometry analysis in monitoring progression of myeloproliferative neoplasms

被引：9

作者：

El Hussein, Siba ^{[1
]}

Yabe, Mariko ^{[2
]}

Wang, Wei ^{[3
]}

Pemmaraju, Naveen ^{[4
]}

Loghavi, Sanam ^{[3
]}

Jelloul, Fatima Zahra ^{[3
]}

Fang, Hong ^{[3
]}

Medeiros, L. Jeffrey ^{[3
]}

Burack, W. Richard ^{[1
]}

Evans, Andrew G. ^{[1
]}

Liesveld, Jane L. ^{[5
,6
]}

Bennett, John M. ^{[1
,5
,6
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Pathol, 601 Elmwood Ave, Rochester, NY 14642 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, Hematopathol Serv, New York, NY USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX USA

[5] Univ Rochester, Med Ctr, Dept Med, Wilmot Canc Inst, Rochester, NY USA

[6] Univ Rochester, Wilmot Canc Inst, Med Ctr, Rochester, NY USA

来源：

EJHAEM | 2022年 / 3卷 / 03期

关键词：

blastic plasmacytoid dendritic cell neoplasm; myeloproliferative neoplasm; polycythemia vera;

D O I：

10.1002/jha2.525

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This report highlights the value of flow cytometry analysis, particularly in the setting of myeloproliferative neoplasms showing features of progression, as neoplastic plasmacytoid dendritic cell (PDC) proliferations may be present, representing either a clonal expansion of mature PDCs related to the underlying myeloproliferative neoplasm or transformation to blastic plasmacytoid dendritic cell neoplasm (BPDCN). BPDCN should always be considered in patients with myeloid neoplasms in progression and/or who develop new cutaneous findings, as it may prompt change of management.

引用

页码：954 / 957

页数：4

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