Hormonal Agents in Localized and Advanced Prostate Cancer: Current Use and Future

被引：1

作者：

Turco, Fabio ^{[1
,2
]}

Buttigliero, Consuelo ^{[2
]}

Delcuratolo, Marco Donatello ^{[2
]}

Gillessen, Silke ^{[1
,3
]}

Vogl, Ursula Maria ^{[1
]}

Zilli, Thomas ^{[3
,4
,5
]}

Fossati, Nicola ^{[6
]}

Gallina, Andrea ^{[6
]}

Farinea, Giovanni ^{[2
]}

Di Stefano, Rosario Francesco ^{[2
]}

Calabrese, Mariangela ^{[2
]}

Saporita, Isabella ^{[2
]}

Crespi, Veronica ^{[2
]}

Poletto, Stefano ^{[2
]}

Palesandro, Erica ^{[7
]}

Di Maio, Massimo ^{[8
]}

Scagliotti, Giorgio Vittorio ^{[2
]}

Tucci, Marcello ^{[7
]}

机构：

[1] Ente Osped Cantonale EOC, IOSI Oncol Inst Southern Switzerland, Dept Oncol, Bellinzona, Switzerland

[2] Univ Turin, San Luigi Gonzaga Hosp, Dept Oncol, Div Med Oncol, Turin, Piedmont, Italy

[3] Univ Svizzera Italiana, Dept Oncol, Lugano, Ticino, Switzerland

[4] EOC, Oncol Inst Southern Switzerland, Dept Oncol Radiat Oncol, Bellinzona, Switzerland

[5] Univ Geneva, Fac Med, Geneva, Switzerland

[6] Univ Svizzera Italiana, Civico USI, Osped Regionale Lugano, Dept Urol, Lugano, Ticino, Switzerland

[7] Cardinal Massaia Hosp, Dept Med Oncol, Corso Dante Alighieri 202, I-14100 Asti, Piedmont, Italy

[8] Univ Turin, Ordine Mauriziano Hosp, Div Med Oncol, Dept Oncol, Turin, Piedmont, Italy

来源：

CLINICAL GENITOURINARY CANCER | 2024年 / 22卷 / 05期

关键词：

Prostate cancer; Hormonal treatment; Androgen deprivation therapy (ADT); Androgen receptor pathway inhibitors (ARPI); ANDROGEN-DEPRIVATION THERAPY; GETUG-AFU; 15; RADICAL PROSTATECTOMY; OPEN-LABEL; ABIRATERONE ACETATE; INCREASED SURVIVAL; DNA-REPAIR; CASTRATION; DOCETAXEL; ENZALUTAMIDE;

D O I：

10.1016/j.clgc.2024.102138

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate cancer (PC) is generally a hormone-dependent tumor. Androgen deprivation therapy ( has been the standard of care in metastatic disease for more than 80 years. Subsequent studies have highlighted the efficacy of ADT even in earlier disease settings such as in localized disease or in the case of biochemical recurrence (BCR). Improved knowledge of PC biology and ADT resistance mechanisms have led to the development of novel generation androgen receptor pathway inhibitors (ARPI). Initially used only in patients who became resistant to ADT, ARPI have subsequently shown to be effective when used in patients with metastatic hormone-naive disease and in recent years their effectiveness has also been evaluated in localized disease and in case of BCR. The objective of this review is to describe the current role of agents interfering with the androgen receptor in different stages of PC and to point out future perspectives.

引用

页数：11

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