Grey Matter Atrophy and its Relationship with White Matter Lesions in Patients with Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Aquaporin-4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder, and Multiple Sclerosis

被引：4

作者：

Cortese, Rosa ^{[1
,2
]}

Battaglini, Marco ^{[1
,3
]}

Prados, Ferran ^{[2
,4
,5
]}

Gentile, Giordano ^{[1
,3
]}

Luchetti, Ludovico ^{[1
,3
]}

Bianchi, Alessia ^{[2
]}

Haider, Lukas ^{[2
]}

Jacob, Anu ^{[6
,7
]}

Palace, Jacqueline ^{[8
]}

Messina, Silvia ^{[8
]}

Paul, Friedemann ^{[9
,10
]}

Marignier, Romain ^{[11
]}

Durand-Dubief, Francoise ^{[11
]}

Rimkus, Carolina de Medeiros ^{[12
]}

Pereira, Samira Luisa Apostolos ^{[13
]}

Sato, Douglas Kazutoshi ^{[14
]}

Filippi, Massimo ^{[15
,16
,17
,18
,19
]}

Rocca, Maria Assunta ^{[15
,16
,19
]}

Cacciaguerra, Laura ^{[15
,16
]}

Rovira, Alex ^{[20
]}

Sastre-Garriga, Jaume ^{[21
]}

Arrambide, Georgina ^{[21
]}

Liu, Yaou ^{[22
]}

Duan, Yunyun ^{[22
]}

Gasperini, Claudio ^{[23
]}

Tortorella, Carla ^{[23
]}

Ruggieri, Serena ^{[24
,25
]}

Amato, Maria Pia ^{[26
,27
]}

Ulivelli, Monica ^{[1
]}

Groppa, Sergiu ^{[28
]}

Grothe, Matthias ^{[29
]}

Llufriu, Sara ^{[30
,31
]}

Sepulveda, Maria ^{[30
,31
]}

Lukas, Carsten ^{[2
,32
,33
]}

Bellenberg, Barbara ^{[32
]}

Schneider, Ruth ^{[32
,33
]}

Sowa, Piotr ^{[34
]}

Celius, Elisabeth G. ^{[35
,36
]}

Probstel, Anne-Katrin ^{[37
,38
,39
]}

Granziera, Cristina ^{[37
,38
,39
,40
]}

Yaldizli, Ozgur ^{[37
,38
,39
]}

Muller, Jannis ^{[37
,38
,39
,40
]}

Stankoff, Bruno ^{[41
]}

Bodini, Benedetta ^{[41
]}

Barkhof, Frederik ^{[4
,42
]}

Ciccarelli, Olga ^{[2
,43
]}

De Stefano, Nicola ^{[1
]}

机构：

[1] Univ Siena, Dept Med Surg & Neurosci, Siena, Italy

[2] UCL, UCL Queen Sq Inst Neurol, Fac Brain Sci, Queen Sq MS Ctr,Dept Neuroinflammat, London, England

[3] SIENA imaging SRL, Siena, Italy

[4] UCL, Ctr Med Imaging Comp Med Phys & Biomed Engn, London, England

[5] Univ Oberta Catalunya, Ehlth Ctr, Barcelona, Spain

[6] Walton Ctr, NMO Clin Serv, Liverpool, England

[7] Cleveland Clin, Dept Neurol, Abu Dhabi, U Arab Emirates

[8] John Radcliffe Hosp, Dept Clin Neurol, Oxford, England

[9] Max Delbrueck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany

[10] Charite Univ med Berlin, Berlin, Germany

[11] Hosp Civils Lyon, Pierre Wertheimer Neurol Hosp, Dept Neurol Multiple Sclerosis Myelin Disorders &, Lyon, France

[12] Univ Sao Paulo FMUSP, Fac Med, Dept Radiol & Oncol, Sao Paulo, Brazil

[13] Univ Sao Paulo FMUSP, Fac Med, Dept Neurol, Sao Paulo, Brazil

[14] Pontifical Catholic Univ Rio Grande Do Sul PUCRS, Sch Med, Porto Alegre, Brazil

[15] IRCCS San Raffaele Sci Inst, Div Neurosci, Neuroimaging Res Unit, Milan, Italy

[16] IRCCS San Raffaele Sci Inst, Neurol Unit, Milan, Italy

[17] IRCCS San Raffaele Sci Inst, Neurorehabil Unit, Milan, Italy

[18] IRCCS San Raffaele Sci Inst, Neurophysiol Serv, Milan, Italy

[19] Univ Vita Salute San Raffaele, Milan, Italy

[20] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Dept Radiol, Sect Neuroradiol, Barcelona, Spain

[21] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Multiple Sclerosis Ctr Catalonia Cemcat, Dept Neurol, Barcelona, Spain

[22] Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing, Peoples R China

[23] S Camillo Forlanini Hosp, Dept Neurosci, Rome, Italy

[24] Sapienza Univ Rome, Dept Human Neurosci, Rome, Italy

[25] IRCSS Fdn St Lucia, Neuroimmunol Unit, Rome, Italy

[26] Univ Florence, Dept Neurofarba, Florence, Italy

[27] IRCCS Don Carlo Gnocchi Fdn, Florence, Italy

[28] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Neurol, Mainz, Germany

[29] Univ Med Greifswald, Dept Neurol, Greifswald, Germany

[30] Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Ctr Neuroimmunol, Serv Neurol,Lab Adv Imaging Neuroimmunol Dis, Barcelona, Spain

[31] Univ Barcelona, Barcelona, Spain

[32] Ruhr Univ Bochum, St Josef Hosp, Inst Neuroradiol, Bochum, Germany

[33] Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany

[34] Oslo Univ Hosp, Div Radiol & Nucl Med, Oslo, Norway

[35] Univ Oslo, Oslo Univ Hosp, Dept Neurol, Oslo, Norway

[36] Univ Oslo, Fac Med, Oslo, Norway

[37] Univ Hosp, Dept Neurol Biomed & Clin Res, Basel, Switzerland

[38] Univ Hosp, Res Ctr Clin Neuroimmunol & Neurosci Basel, Basel, Switzerland

[39] Univ Basel, Basel, Switzerland

[40] Univ Hosp Basel, Dept Biomed Engn, Translat Imaging Neurol ThINk Basel, Basel, Switzerland

[41] Sorbonne Univ, Pitie Salpetriere Hosp, Paris Brain Inst, ICM, Paris, France

[42] Vrije Univ Amsterdam, Radiol & Nucl Med, Med Ctr, Amsterdam, Netherlands

[43] Univ Coll London Hosp UCLH, Natl Inst Hlth Res NIHR, Biomed Res Ctr, London, England

来源：

ANNALS OF NEUROLOGY | 2024年 / 96卷 / 02期

关键词：

NEURODEGENERATION; DEMYELINATION; MECHANISMS; CRITERIA; DAMAGE;

D O I：

10.1002/ana.26951

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To evaluate: (1) the distribution of gray matter (GM) atrophy in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD), and relapsing-remitting multiple sclerosis (RRMS); and (2) the relationship between GM volumes and white matter lesions in various brain regions within each disease. Methods: A retrospective, multicenter analysis of magnetic resonance imaging data included patients with MOGAD/AQP4+NMOSD/RRMS in non-acute disease stage. Voxel-wise analyses and general linear models were used to evaluate the relevance of regional GM atrophy. For significant results (p < 0.05), volumes of atrophic areas are reported. Results: We studied 135 MOGAD patients, 135 AQP4+NMOSD, 175 RRMS, and 144 healthy controls (HC). Compared with HC, MOGAD showed lower GM volumes in the temporal lobes, deep GM, insula, and cingulate cortex (75.79 cm(3)); AQP4+NMOSD in the occipital cortex (32.83 cm(3)); and RRMS diffusely in the GM (260.61 cm(3)). MOGAD showed more pronounced temporal cortex atrophy than RRMS (6.71 cm(3)), whereas AQP4+NMOSD displayed greater occipital cortex atrophy than RRMS (19.82 cm(3)). RRMS demonstrated more pronounced deep GM atrophy in comparison with MOGAD (27.90 cm(3)) and AQP4+NMOSD (47.04 cm(3)). In MOGAD, higher periventricular and cortical/juxtacortical lesions were linked to reduced temporal cortex, deep GM, and insula volumes. In RRMS, the diffuse GM atrophy was associated with lesions in all locations. AQP4+NMOSD showed no lesion/GM volume correlation. Interpretation: GM atrophy is more widespread in RRMS compared with the other two conditions. MOGAD primarily affects the temporal cortex, whereas AQP4+NMOSD mainly involves the occipital cortex. In MOGAD and RRMS, lesion-related tract degeneration is associated with atrophy, but this link is absent in AQP4+NMOSD. ANN NEUROL 2024

引用

页码：276 / 288

页数：13

共 50 条

[1] Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology [J].

Abbott, NJ .

NEUROCHEMISTRY INTERNATIONAL, 2004, 45 (04) :545-552

[2] Difference in the Source of Anti-AQP4-IgG and Anti-MOG-IgG Antibodies in CSF in Patients With Neuromyelitis Optica Spectrum Disorder [J].

Akaishi, Tetsuya ;

Takahashi, Toshiyuki ;

Misu, Tatsuro ;

Kaneko, Kimihiko ;

Takai, Yoshiki ;

Nishiyama, Shuhei ;

Ogawa, Ryo ;

Fujimori, Juichi ;

Ishii, Tadashi ;

Aoki, Masashi ;

Fujihara, Kazuo ;

Nakashima, Ichiro .

NEUROLOGY, 2021, 97 (01) :E1-E12

[3]

Andersson J. L., 2007, NONLINEAR REGISTRATI

[4] Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria [J].

Banwell, Brenda ;

Bennett, Jeffrey L. ;

Marignier, Romain ;

Kim, Ho Jin ;

Brilot, Fabienne ;

Flanagan, Eoin P. ;

Ramanathan, Sudarshini ;

Waters, Patrick ;

Tenembaum, Silvia ;

Graves, Jennifer S. ;

Chitnis, Tanuja ;

Brandt, Alexander U. ;

Hemingway, Cheryl ;

Neuteboom, Rinze ;

Pandit, Lekha ;

Reindl, Markus ;

Saiz, Albert ;

Sato, Douglas Kazutoshi ;

Rostasy, Kevin ;

Paul, Friedemann ;

Pittock, Sean J. ;

Fujihara, Kazuo ;

Palace, Jacqueline .

LANCET NEUROLOGY, 2023, 22 (03) :268-282

[5] White Matter Atrophy and Cognitive Dysfunctions in Neuromyelitis Optica [J].

Blanc, Frederic ;

Noblet, Vincent ;

Jung, Barbara ;

Rousseau, Francois ;

Renard, Felix ;

Bourre, Bertrand ;

Longato, Nadine ;

Cremel, Nadjette ;

Di Bitonto, Laure ;

Kleitz, Catherine ;

Collongues, Nicolas ;

Foucher, Jack ;

Kremer, Stephane ;

Armspach, Jean-Paul ;

de Seze, Jerome .

PLOS ONE, 2012, 7 (04)

[6] Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis [J].

Bodini, Benedetta ;

Veronese, Mattia ;

Garcia-Lorenzo, Daniel ;

Battaglini, Marco ;

Poirion, Emilie ;

Chardain, Audrey ;

Freeman, Leorah ;

Louapre, Celine ;

Tchikviladze, Maya ;

Papeix, Caroline ;

Dolle, Frederic ;

Zalc, Bernard ;

Lubetzki, Catherine ;

Bottlaender, Michel ;

Turkheimer, Federico ;

Stankoff, Bruno .

ANNALS OF NEUROLOGY, 2016, 79 (05) :726-738

[7] Quantitative MRI identifies lesional and non-lesional abnormalities in MOGAD [J].

Brier, Matthew R. ;

Xiang, Biao ;

Ciotti, John R. ;

Chahin, Salim ;

Wu, Gregory F. ;

Naismith, Robert T. ;

Yablonskiy, Dmitriy ;

Cross, Anne H. .

MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2023, 73

[8] Timing and Predictors of T2-Lesion Resolution in Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease [J].

Cacciaguerra, Laura ;

Redenbaugh, Vyanka ;

Chen, John J. ;

Morris, Pearse ;

Sechi, Elia ;

Syc-Mazurek, Stephanie B. ;

Lopez-Chiriboga, A. Sebastian ;

Tillema, Jan-Mendelt ;

Rocca, Maria A. ;

Filippi, Massimo ;

Pittock, Sean J. ;

Flanagan, Eoin P. .

NEUROLOGY, 2023, 101 (13) :E1376-E1381

[9] Exploring the origins of grey matter damage in multiple sclerosis [J].

Calabrese, Massimiliano ;

Magliozzi, Roberta ;

Ciccarelli, Olga ;

Geurts, Jeroen J. G. ;

Reynolds, Richard ;

Martin, Roland .

NATURE REVIEWS NEUROSCIENCE, 2015, 16 (03) :147-158

[10] Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders [J].

Ciccarelli, Olga ;

Cohen, Jeffrey A. ;

Reingold, Stephen C. ;

Weinshenker, Brian G. ;

Amato, Maria Pia ;

Banwell, Brenda ;

Barkhof, Frederik ;

Bebo, Bruce ;

Becher, Burkhard ;

Bethoux, Francois ;

Brandt, Alexander ;

Brownlee, Wallace ;

Calabresi, Peter ;

Chatway, Jeremy ;

Chien, Claudia ;

Chitnis, Tanuja ;

Ciccarelli, Olga ;

Cohen, Jeffrey ;

Comi, Giancarlo ;

Correale, Jorge ;

De Seze, Jerome ;

De Stefano, Nicola ;

Fazekas, Franz ;

Flanagan, Eoin ;

Freedman, Mark ;

Fujihara, Kazuo ;

Galetta, Steven ;

Goldman, Myla ;

Greenberg, Benjamin ;

Hartung, Hans-Peter ;

Hemmer, Bernhard ;

Henning, Anke ;

Izbudak, Izlem ;

Kappos, Ludwig ;

Lassmann, Hans ;

Laule, Cornelia ;

Levy, Michael ;

Lublin, Fred ;

Lucchinetti, Claudia ;

Lukas, Carsten ;

Marrie, Ruth Ann ;

Miller, Aaron ;

Miller, David ;

Montalban, Xavier ;

Mowry, Ellen ;

Ourselin, Sebastien ;

Paul, Friedemann ;

Pelletier, Daniel ;

Ranjeva, Jean-Philippe ;

Reich, Daniel .

LANCET NEUROLOGY, 2019, 18 (02) :185-197

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