The associations of serum vitamin D status and vitamin D supplements use with all-cause dementia, Alzheimer ' s disease, and vascular dementia: a UK Biobank based prospective cohort study

被引:13
作者
Chen, Li-Ju [1 ]
Sha, Sha [1 ]
Stocker, Hannah [2 ,4 ]
Brenner, Hermann [1 ,2 ,3 ,5 ]
Ben Schoettker [1 ,2 ]
机构
[1] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, Heidelberg, Germany
[2] Heidelberg Univ, Network Aging Res, Heidelberg, Germany
[3] German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany
[4] Natl Ctr Tumor Dis NCT, Heidelberg, Germany
[5] German Canc Consortium DKTK, German Canc Res Ctr DKFZ, Heidelberg, Germany
基金
英国惠康基金; 英国医学研究理事会;
关键词
vitamin D; dementia; Alzheimer ' s disease; vascular dementia; cohort study; BONE-MINERAL DENSITY; D DEFICIENCY; COGNITIVE PERFORMANCE; AMYLOID-BETA; RISK; IMPAIRMENT; ADULTS;
D O I
10.1016/j.ajcnut.2024.01.020
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Prior studies on vitamin D and dementia outcomes yielded mixed results and had several important limitations. Objectives: We aimed to assess the associations of both serum vitamin D status and supplementation with all -cause dementia, Alzheimer ' s disease (AD), and vascular dementia (VD) incidence. Methods: With a prospective cohort study design, we comprehensively assessed the associations of vitamin D and multivitamin supplementation, as well as vitamin D deficiency {25-hydroxyvitamin D [25(OH)D] < 30 nmol/L}, and insufficiency [25(OH)D 30 to < 50 nmol/L], with the 14 -year incidence of all -cause dementia, AD, and VD in 269,229 participants, aged 55 to 69, from the UK Biobank. Results: Although 5.0% reported regular vitamin D use and 19.8% reported multivitamin use, the majority of participants exhibited either vitamin D deficiency (18.3%) or insufficiency (34.0%). However, vitamin D deficiency was less prevalent among users of vitamin D (6.9%) or multivitamin preparations (9.5%) than among nonusers (21.5%). Adjusted Cox regression models demonstrated 19% to 25% increased risk of all 3 dementia outcomes for those with vitamin D deficiency [hazard ratio (HR) 95% confidence interval (CI)]: 1.25 (1.16, 1.34) for all -cause dementia; 1.19 (1.07 - 1.31) for AD; 1.24 (1.08 - 1.43) for VD] and 10% to 15% increased risk of those with vitamin D insufficiency [HR (95% CI): 1.11 (1.05, 1.18) for all -cause dementia; 1.10 (1.02 - 1.19) for AD; 1.15 (1.03 - 1.29) for VD]. Regular users of vitamin D and multivitamins had 17% and 14% lower risk of AD [HR (95% CI): 0.83 (0.71, 0.98)] and VD [HR (95% CI): 0.86 (0.75, 0.98)] incidence, respectively. Conclusions: Although our findings indicate the potential bene fi ts of vitamin D supplementation for dementia prevention, randomized controlled trials are essential for definitive evidence.
引用
收藏
页码:1052 / 1064
页数:13
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