Molecular and Pathological Features of Paediatric High-Grade Gliomas

被引：2

作者：

Blasco-Santana, Luis ^{[1
]}

Colmenero, Isabel ^{[1
]}

机构：

[1] Hosp Infantil Univ Nino Jesus, Pathol Dept, Ave Menendez Pelayo, 65, Madrid 28009, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 15期

关键词：

glioblastoma; glioma; paediatric glioma; brain tumour; histone; 3; INTRINSIC PONTINE GLIOMAS; DIFFUSE MIDLINE GLIOMAS; HISTONE H3.3; GLIOBLASTOMA-MULTIFORME; IMAGING CHARACTERISTICS; K27M MUTATIONS; SUBGROUPS; TUMORS; DEFINE; H3F3A;

D O I：

10.3390/ijms25158498

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Paediatric high-grade gliomas are among the most common malignancies found in children. Despite morphological similarities to their adult counterparts, there are profound biological and molecular differences. Furthermore, and thanks to molecular biology, the diagnostic pathology of paediatric high-grade gliomas has experimented a dramatic shift towards molecular classification, with important prognostic implications, as is appropriately reflected in both the current WHO Classification of Tumours of the Central Nervous System and the WHO Classification of Paediatric Tumours. Emphasis is placed on histone 3, IDH1, and IDH2 alterations, and on Receptor of Tyrosine Kinase fusions. In this review we present the current diagnostic categories from the diagnostic pathology perspective including molecular features.

引用

页数：25

共 101 条

[1] Imaging Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3 K27M Mutation [J].

Aboian, M. S. ;

Solomon, D. A. ;

Felton, E. ;

Mabray, M. C. ;

Villanueva-Meyer, J. E. ;

Mueller, S. ;

Cha, S. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2017, 38 (04) :795-800

[2]

Aghajan Yasmin, 2016, BMJ Case Rep, V2016, DOI 10.1136/bcr-2016-217189

[3] H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components [J].

Andreiuolo, Felipe ;

Lisner, Tomo ;

Zlocha, Jozef ;

Kramm, Christof ;

Koch, Arend ;

Bison, Brigitte ;

Gareton, Albane ;

Zanello, Marc ;

Waha, Andreas ;

Varlet, Pascale ;

Pietsch, Torsten .

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2019, 7 (1) :78

[4] A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation [J].

Auffret, Lucie ;

Ajlil, Yassine ;

Tauziede-Espariat, Arnault ;

Kergrohen, Thomas ;

Puiseux, Chloe ;

Riffaud, Laurent ;

Blouin, Pascale ;

Bertozzi, Anne-Isabelle ;

Leblond, Pierre ;

Blomgren, Klas ;

Froelich, Sebastien ;

Picca, Alberto ;

Touat, Mehdi ;

Sanson, Marc ;

Beccaria, Kevin ;

Blauwblomme, Thomas ;

Dangouloff-Ros, Volodia ;

Boddaert, Nathalie ;

Varlet, Pascale ;

Debily, Marie-Anne ;

Grill, Jacques ;

Castel, David .

ACTA NEUROPATHOLOGICA, 2024, 147 (01)

[5] Absence of MGMT promoter methylation in diffuse midline glioma, H3 K27M-mutant [J].

Banan, Rouzbeh ;

Christians, Arne ;

Bartels, Stephan ;

Lehmann, Ulrich ;

Hartmann, Christian .

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2017, 5

[6] Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas [J].

Bender, Sebastian ;

Tang, Yujie ;

Lindroth, Anders M. ;

Hovestadt, Volker ;

Jones, David T. W. ;

Kool, Marcel ;

Zapatka, Marc ;

Northcott, Paul A. ;

Sturm, Dominik ;

Wang, Wei ;

Radlwimmer, Bernhard ;

Hojfeldt, Jonas W. ;

Truffaux, Nathalene ;

Castel, David ;

Schubert, Simone ;

Ryzhova, Marina ;

Seker-Cin, Huriye ;

Gronych, Jan ;

Johann, Pascal David ;

Stark, Sebastian ;

Meyer, Jochen ;

Milde, Till ;

Schuhmann, Martin ;

Ebinger, Martin ;

Monoranu, Camelia-Maria ;

Ponnuswami, Anitha ;

Chen, Spenser ;

Jones, Chris ;

Witt, Olaf ;

Collins, V. Peter ;

von Deimling, Andreas ;

Jabado, Nada ;

Puget, Stephanie ;

Grill, Jacques ;

Helin, Kristian ;

Korshunov, Andrey ;

Lichter, Peter ;

Monje, Michelle ;

Plass, Christoph ;

Cho, Yoon-Jae ;

Pfister, Stefan M. .

CANCER CELL, 2013, 24 (05) :660-672

[7] Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN [J].

Bjerke, Lynn ;

Mackay, Alan ;

Nandhabalan, Meera ;

Burford, Anna ;

Jury, Alexa ;

Popov, Sergey ;

Bax, Dorine A. ;

Carvalho, Diana ;

Taylor, Kathryn R. ;

Vinci, Maria ;

Bajrami, Ilirjana ;

McGonnell, Imelda M. ;

Lord, Christopher J. ;

Reis, Rui M. ;

Hargrave, Darren ;

Ashworth, Alan ;

Workman, Paul ;

Jones, Chris .

CANCER DISCOVERY, 2013, 3 (05) :512-519

[8] Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency [J].

Bouffet, Eric ;

Larouche, Valerie ;

Campbell, Brittany B. ;

Merico, Daniele ;

de Borja, Richard ;

Aronson, Melyssa ;

Durno, Carol ;

Krueger, Joerg ;

Cabric, Vanja ;

Ramaswamy, Vijay ;

Zhukova, Nataliya ;

Mason, Gary ;

Farah, Roula ;

Afzal, Samina ;

Yalon, Michal ;

Rechavi, Gideon ;

Magimairajan, Vanan ;

Walsh, Michael F. ;

Constantini, Shlomi ;

Dvir, Rina ;

Elhasid, Ronit ;

Reddy, Alyssa ;

Osborn, Michael ;

Sullivan, Michael ;

Hansford, Jordan ;

Dodgshun, Andrew ;

Klauber-Demore, Nancy ;

Peterson, Lindsay ;

Patel, Sunil ;

Lindhorst, Scott ;

Atkinson, Jeffrey ;

Cohen, Zane ;

Laframboise, Rachel ;

Dirks, Peter ;

Taylor, Michael ;

Malkin, David ;

Albrecht, Steffen ;

Dudley, Roy W. R. ;

Jabado, Nada ;

Hawkins, Cynthia E. ;

Shlien, Adam ;

Tabori, Uri .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (19) :2206-+

[9] Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants [J].

Bressan, Raul Bardini ;

Southgate, Benjamin ;

Ferguson, Kirsty M. ;

Blin, Carla ;

Grant, Vivien ;

Alfazema, Neza ;

Wills, Jimi C. ;

Marques-Torrejon, Maria Angeles ;

Morrison, Gillian M. ;

Ashmore, James ;

Robertson, Faye ;

Williams, Charles A. C. ;

Bradley, Leanne ;

von Kriegsheim, Alex ;

Anderson, Richard A. ;

Tomlinson, Simon R. ;

Pollard, Steven M. .

CELL STEM CELL, 2021, 28 (05) :877-+

[10] Bithalamic gliomas may be molecularly distinct from their unilateral high-grade counterparts [J].

Broniscer, Alberto ;

Hwang, Scott N. ;

Chamdine, Omar ;

Lin, Tong ;

Pounds, Stanley ;

Onar-Thomas, Arzu ;

Chi, Lei ;

Shurtleff, Sheila ;

Allen, Sariah ;

Gajjar, Amar ;

Northcott, Paul ;

Orr, Brent A. .

BRAIN PATHOLOGY, 2018, 28 (01) :112-120

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