Progesterone and estradiol alleviate Poly I:C-induced immune response in endometrial stromal cells

被引：0
|
作者：
Su, Changqi [1 ]
Chen, Xuanyu [1 ]
Zhang, Shilin [1 ]
Wang, Chun [1 ]
Yang, Cuiting [1 ]
Arab, Khan [1 ]
Zeng, Yutian [1 ]
Zhou, Guangbin [1 ,2 ,3 ]
Zeng, Changjun [1 ,2 ,3 ]
Zhang, Ming [1 ,2 ,3 ]
机构：
[1] Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Peoples R China
[2] Sichuan Agr Univ, Coll Anim Sci & Technol, Key Lab Livestock & Poultry Multiom, Minist Agr & Rural Affairs, Chengdu 611130, Peoples R China
[3] Sichuan Agr Univ, Coll Anim Sci & Technol, Farm Anim Genet Resources Explorat & Innovat Key L, Chengdu 611130, Peoples R China
来源：
JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2024年 / 166卷
关键词：
Poly(I:C); Immune cytokines; Progesterone; Estradiol; Endometrial stromal cells; ESTROGEN-RECEPTOR-ALPHA; TOLL-LIKE RECEPTORS; SIGNALING PATHWAY; EXPRESSION; BETA; LIPOPOLYSACCHARIDE; PREGNANCY; CHEMOKINE; CYTOKINE; UTERUS;
D O I：
10.1016/j.jri.2024.104318
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Progesterone (P) and estradiol (E2) regulate the immune status of the uterus. However, whether P and E2 can affect the immune response of endometrial cell is still unknown. In the study, primary endometrial stromal cells (EndSCs) were treated with Poly(I:C), the pathogen-associated molecular pattern of double-stranded RNA (dsRNA) virus, to induce immune response, and then EndSCs were stimulated with P or/and E2. The results showed Poly(I:C) up-regulated the expression of immune cytokines IL-6, IL-8, IL-1 beta and TNF-alpha, and significantly down-regulated the expression of ER alpha and PGRMC1 in EndSCs. Moreover, P or low-dose of E2 attenuate Poly(I: C)-induced immune response, and then the synergistic effects of P and E2 decreased expression of ER alpha, ER beta and PGR, and alleviate the decease of PGRMC1 induced by Poly(I:C), but not alleviate the decease of ER alpha caused by Poly(I:C). The result provides a steroid therapeutic method to suppress dsRNA virtues-induced immune response through the synergistic effect of P and E2 on endometrial stromal cells.
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页数：8
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