EV-mediated intercellular communication in acute myeloid leukemia: Transport of genetic materials in the bone marrow microenvironment

被引：3
作者：
Zhou, Qi [1 ]
Li, Zijian [1 ,2 ]
Xi, Yaming [1 ,2 ]
机构：
[1] Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China
[2] Lanzhou Univ, Hosp 1, Dept Hematol, First Dong Gang Xi Rd, Lanzhou, Gansu, Peoples R China
来源：
EXPERIMENTAL HEMATOLOGY | 2024年 / 133卷
关键词：
MESENCHYMAL STEM-CELLS; EXTRACELLULAR VESICLES; PLASMA EXOSOME; STROMAL CELLS; DISEASE; PROLIFERATION; TRANSCRIPTION; TRAFFICKING; RESISTANCE; EXPRESSION;
D O I：
10.1016/j.exphem.2024.104175
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute myeloid leukemia (AML) is a common hematological cancer. Cancer cells exchange information with the surrounding microenvironment, which can be transmitted by extracellular vesicles (EVs). In recent years, the genetic materials transported by EVs have attracted attention due to their important roles in different pathological processes. EV-derived ncRNAs (EV-ncRNAs) regulate physiological functions and maintain homeostasis, mainly including microRNAs, long noncoding RNAs, and circular RNAs. However, the mechanism of involvement and potential clinical application of EV-ncRNAs in AML have not been reported. Given the unique importance of the bone marrow microenvironment (BMME) for AML, a greater understanding of the communication between leukemic cells and the BMME is needed to improve the prognosis of patients and reduce the incidence of recurrence. Additionally, studies on leukemic EV-ncRNA transport guide the design of new diagnostic and therapeutic tools for AML. This review systematically describes intercellular communication in the BMME of AML and emphasizes the role of EVs. More importantly, we focus on the information transmission of EV-ncRNAs in the BMME to explore their clinical application as potential biomarkers and therapeutic targets. (c) 2024 Published by Elsevier Inc. on behalf of ISEH - Society for Hematology and Stem Cells.
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页数：15
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