Continuous Associations between Remote Self-Administered Cognitive Measures and Imaging Biomarkers of Alzheimer's Disease

被引：6

作者：

Boots, E. A. ^{[1
]}

Frank, R. D. ^{[2
]}

Fan, W. Z. ^{[2
]}

Christianson, T. J. ^{[2
]}

Kremers, W. K. ^{[2
]}

Stricker, J. L. ^{[3
]}

Machulda, M. M. ^{[1
]}

Fields, J. A. ^{[1
]}

Hassenstab, J. ^{[4
]}

Graff-Radford, J. ^{[5
]}

Vemuri, P. ^{[6
]}

Jack, C. R. ^{[6
]}

Knopman, D. S. ^{[5
]}

Petersen, R. C. ^{[5
]}

Stricker, Nikki H. ^{[1
,7
]}

机构：

[1] Mayo Clin, Dept Psychiat & Psychol, Divison Neurocognit Disorders, Rochester, MN USA

[2] Mayo Clin, Dept Quantitat Hlth Sci, Div Biomed Stat & Informat, Rochester, MN USA

[3] Mayo Clin, Dept Informat Technol, Rochester, MN USA

[4] Washington Univ St Louis, Dept Neurol & Psychol & Brain Sci, St Louis, MO USA

[5] Mayo Clin, Dept Neurol, Rochester, MN USA

[6] Mayo Clin, Dept Radiol, Rochester, MN USA

[7] Mayo Clin, ABPP CN, 200 First St SW, Rochester, MN 55905 USA

来源：

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE | 2024年 / 11卷 / 05期

关键词：

Digital health; amyloid; mild cognitive impairment; Mayo Test Drive; Neuropsychological Tests; MENTAL STATUS; IMPAIRMENT; MCI;

D O I：

10.14283/jpad.2024.99

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Easily accessible and self-administered cognitive assessments that can aid early detection for Alzheimer's disease (AD) dementia risk are critical for timely intervention.Objectives/Design This cross-sectional study investigated continuous associations between Mayo Test Drive (MTD)-a remote, self-administered, multi-device compatible, web-based cognitive assessment-and AD-related imaging biomarkers.Participants/Setting 684 adults from the Mayo Clinic Study of Aging and Mayo Clinic Alzheimer's Disease Research Center participated (age=70.4 +/- 11.2, 49.7% female). Participants were predominantly cognitively unimpaired (CU; 94.0%).Measurements Participants completed (1) brain amyloid and tau PET scans and MRI scans for hippocampal volume (HV) and white matter hyperintensities (WMH); (2) MTD remotely, consisting of the Stricker Learning Span and Symbols Test which combine into an MTD composite; and (3) in-person neuropsychological assessment including measures to obtain Mayo Preclinical Alzheimer's disease Cognitive Composite (Mayo-PACC) and Global-z. Multiple regressions adjusted for age, sex, and education queried associations between imaging biomarkers and scores from remote and in-person cognitive measures.Results Lower performances on MTD were associated with greater amyloid, entorhinal tau, and global tau PET burden, lower HV, and higher WMH. Mayo-PACC and Global-z were associated with all imaging biomarkers except global tau PET burden. MCI/Dementia participants showed lower performance on all MTD measures compared to CU with large effect sizes (Hedge's g's=1.65-2.02), with similar findings for CU versus MCI only (Hedge's g's=1.46-1.83).Conclusion MTD is associated with continuous measures of AD-related imaging biomarkers, demonstrating ability to detect subtle cognitive change using a brief, remote assessment in predominantly CU individuals and criterion validity for MTD.

引用

页码：1467 / 1479

页数：13

共 62 条

[1] Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease [J].

Alawode, D. O. T. ;

Heslegrave, A. J. ;

Ashton, N. J. ;

Karikari, T. K. ;

Simren, J. ;

Montoliu-Gaya, L. ;

Pannee, J. ;

O'Connor, A. ;

Weston, P. S. J. ;

Lantero-Rodriguez, J. ;

Keshavan, A. ;

Snellman, A. ;

Gobom, J. ;

Paterson, R. W. ;

Schott, J. M. ;

Blennow, K. ;

Fox, N. C. ;

Zetterberg, H. .

JOURNAL OF INTERNAL MEDICINE, 2021, 290 (03) :583-601

[2] Mayo normative studies: A conditional normative model for longitudinal change on the Auditory Verbal Learning Test and preliminary validation in preclinical Alzheimer's disease [J].

Alden, Eva C. ;

Lundt, Emily S. ;

Twohy, Erin L. ;

Christianson, Teresa J. ;

Kremers, Walter K. ;

Machulda, Mary M. ;

Jack, Clifford R. ;

Knopman, David S. ;

Mielke, Michelle M. ;

Petersen, Ronald C. ;

Stricker, Nikki H. .

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, 2022, 14 (01)

[3] Diagnostic accuracy of the Cogstate Brief Battery for prevalent MCI and prodromal AD (MCI A+T+) in a population-based sample [J].

Alden, Eva C. ;

Pudumjee, Shehroo B. ;

Lundt, Emily S. ;

Albertson, Sabrina M. ;

Machulda, Mary M. ;

Kremers, Walter K. ;

Jack, Clifford R., Jr. ;

Knopman, David S. ;

Petersen, Ronald C. ;

Mielke, Michelle M. ;

Stricker, Nikki H. .

ALZHEIMERS & DEMENTIA, 2021, 17 (04) :584-594

[4]

American Psychiatric Association, 2013, Diagnostic and Statistical Manual of Mental Disorders, DOI DOI 10.1176/APPI.BOOKS.9780890425596

[5] Unified segmentation [J].

Ashburner, J ;

Friston, KJ .

NEUROIMAGE, 2005, 26 (03) :839-851

[6] Unsupervised Online Paired Associates Learning Task from the Cambridge Neuropsychological Test Automated Battery (CANTAB®) in the Brain Health Registry [J].

Ashford, Miriam T. ;

Aaronson, A. ;

Kwang, W. ;

Eichenbaum, J. ;

Gummadi, S. ;

Jin, C. ;

Cashdollar, N. ;

Thorp, E. ;

Wragg, E. ;

Zavitz, K. H. ;

Cormack, F. ;

Banh, T. ;

Neuhaus, J. M. ;

Ulbricht, A. ;

Camacho, M. R. ;

Fockler, J. ;

Flenniken, D. ;

Truran, D. ;

Mackin, R. S. ;

Weiner, M. W. ;

Nosheny, R. L. .

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE, 2024, 11 (02) :514-524

[7] A reproducible evaluation of ANTs similarity metric performance in brain image registration [J].

Avants, Brian B. ;

Tustison, Nicholas J. ;

Song, Gang ;

Cook, Philip A. ;

Klein, Arno ;

Gee, James C. .

NEUROIMAGE, 2011, 54 (03) :2033-2044

[8] Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data [J].

Bos, Isabelle ;

Vos, Stephanie J. B. ;

Jansen, Willemijn J. ;

Vandenberghe, Rik ;

Gabel, Silvy ;

Estanga, Ainara ;

Ecay-Torres, Mirian ;

Tomassen, Jori ;

den Braber, Anouk ;

Lleo, Alberto ;

Sala, Isabel ;

Wallin, Anders ;

Kettunen, Petronella ;

Molinuevo, Jose L. ;

Rami, Lorena ;

Chetelat, Gael ;

de la Sayette, Vincent ;

Tsolaki, Magda ;

Freund-Levi, Yvonne ;

Johannsen, Peter ;

Novak, Gerald P. ;

Ramakers, Inez ;

Verhey, Frans R. ;

Visser, Pieter Jelle .

FRONTIERS IN AGING NEUROSCIENCE, 2018, 10

[9] To what degree is late life cognitive decline driven by age-related neuropathologies? [J].

Boyle, Patricia A. ;

Wang, Tianhao ;

Yu, Lei ;

Wilson, Robert S. ;

Dawe, Robert ;

Arfanakis, Konstantinos ;

Schneider, Julie A. ;

Bennett, David A. .

BRAIN, 2021, 144 :2166-2175

[10] The neuropsychology of normal aging and preclinical Alzheimer's disease [J].

Caselli, Richard J. ;

Locke, Dona E. C. ;

Dueck, Amylou C. ;

Knopman, David S. ;

Woodruff, Bryan K. ;

Hoffman-Snyder, Charlene ;

Rademakers, Rosa ;

Fleisher, Adam S. ;

Reiman, Eric M. .

ALZHEIMERS & DEMENTIA, 2014, 10 (01) :84-92

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