Menthol-Modified Quercetin Liposomes with Brain-Targeting Function for the Treatment of Senescent Alzheimer's Disease

被引：3

作者：

Liu, Wan-ying ^{[1
]}

Yu, Yang ^{[1
]}

Zang, Juan ^{[1
]}

Liu, Yang ^{[1
]}

Li, Feng-rui ^{[1
]}

Zhang, Lu ^{[1
]}

Guo, Rui-bo ^{[1
]}

Kong, Liang ^{[1
]}

Ma, Ling-yue ^{[2
]}

Li, Xue-tao ^{[1
]}

机构：

[1] Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian 116600, Peoples R China

[2] Peking Univ First Hosp, Dept Pharm, Beijing 100034, Peoples R China

来源：

ACS CHEMICAL NEUROSCIENCE | 2024年 / 15卷 / 11期

基金：

中国博士后科学基金;

关键词：

quercetin; menthol; blood-brain barrier; aging; Alzheimer's disease; BARRIER; INFLAMMATION; BDNF;

D O I：

10.1021/acschemneuro.4c00109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidative stress and neuroinflammation in the aging brain are correlated with the development of neurodegenerative diseases, such as Alzheimer's disease (AD). The blood-brain barrier (BBB) poses a significant challenge to the effective delivery of therapeutics for AD. Prior research has demonstrated that menthol (Men) can augment the permeability of the BBB. Consequently, in the current study, we modified Men on the surface of liposomes to construct menthol-modified quercetin liposomes (Men-Qu-Lips), designed to cross the BBB and enhance quercetin (Qu) concentration in the brain for improved therapeutic efficacy. The experimental findings indicate that Men-Qu-Lips exhibited good encapsulation efficiency and stability, successfully crossed the BBB, improved oxidative stress and neuroinflammation in the brains of aged mice, protected neurons, and enhanced their learning and memory abilities.

引用

页码：2283 / 2295

页数：13

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