Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

被引:3
作者
Yang, Yaqi [1 ]
Lin, Yumeng [2 ]
Han, Zhongyu [1 ,2 ]
Wang, Bo [3 ]
Zheng, Wei [3 ]
Wei, Lijuan [3 ]
机构
[1] Changchun Univ Chinese Med, Coll Chinese Med, Changchun, Jilin, Peoples R China
[2] Southeast Univ, Naniing Tongren Hosp, Sch Med, Nanjing, Peoples R China
[3] Changchun Univ Tradit Chinese Med, Ophthalmol Dept, Affiliated Hosp, Changchun, Jilin, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
ferroptosis; metabolic pathway; eye diseases; therapy; corneal injury; PIGMENT EPITHELIAL-CELLS; OXIDATIVE STRESS; LIPID-PEROXIDATION; RETINAL DEGENERATION; DIABETIC-RETINOPATHY; IRON HOMEOSTASIS; LENS EPITHELIUM; DOWN-REGULATION; MOUSE MODEL; CANCER;
D O I
10.3389/fimmu.2024.1440309
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.
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页数:28
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