In vitro anticancer, antioxidant, antimicrobial, antileishmanial, enzymes inhibition and in vivo anti-inflammatory activities of organotin(IV) derivatives of 4-bromophenoxyacetic acid

Organotin(IV) derivatives {( n -C 4 H 9 ) 3 SnL ( 1 ), (CH 3 ) 3 SnL ( 2 ), ( n -C 4 H 9 ) 2 SnL 2 ( 3 ) and (CH 3 ) 2 SnL 2 ( 4 )} of 4-bromophenoxyacetic acid ( HL ) were synthesized and characterized by elemental, FT -IR, NMR and single crystal XRD diffraction analyses. The carboxylate ligand showed bridging/chelating bidentate coordination. The complexes 1 and 2 have adopted polymeric chain structures consisting tin atoms in distorted trigonal bipyramidal geometry. Complex 3 has shown highest DPPH radical scavenging (IC 50 = 33.46 mu g/mL) and antileishmanial activity (IC 50 = 27.06 mu g/mL). Complex 3 was also the most efficient agent in acetylcholinesterase (IC 50 = 5.12 mu g/mL), butyrylcholinesterase (IC 50 = 13.79 mu g/mL) and Monoamine oxidase (IC 50 = 8.50 mu g/mL) inhibition assays. Complex 4 (IC 50 = 18.73 mu g/mL) was the most potent ABTS radical scavenger. Complex 1 with IC 50 values of 27.50 and 71.32 mu g/mL was the most efficient alpha-glucosidase and dipeptidyl peptidase-4 enzyme inhibitor, respectively. While complex 2 was found the most potent Cyclooxygenase-2 (7.81 mu g/mL) and 5-Lioxygenase (6.69 mu g/mL) inhibitor. MTT assay revealed highest inhibitory potency of complexes 4 (IC 50 = 8.035 +/- 0.05 mu g/ml), and 1 (IC 50 =10.16 +/- 0.17 mu g/ml) towards the brain cancer cell line. The in vivo study performed on mice have shown potent anti-inflammatory effects of 1 and 2 comparable to the standard, indomethacin.