Clozapine-Related Functional Bowel Obstruction: A Rare Adverse Effect Unmasking Quetiapine and Benztropine Interaction Raising Need for Bowel Surveillance

被引：0

作者：

Tiwari, Apoorv ^{[1
]}

Kambhatla, Swathi ^{[2
]}

George, Nathan ^{[3
]}

Anumolu, Prathyusha ^{[1
]}

Malik, Nikhale ^{[1
]}

Kambhatla, Sujata ^{[1
]}

机构：

[1] Michigan State Univ, Garden City Hosp, Dept Internal Med, Garden City, MI 48135 USA

[2] Michigan State Univ, Garden City, MI USA

[3] Garden City Hosp, Garden City, MI USA

来源：

ACG CASE REPORTS JOURNAL | 2024年 / 11卷 / 05期

关键词：

Clozapine; CIGH; bowel surveillance; ileus; GASTROINTESTINAL HYPOMOTILITY;

D O I：

10.14309/crj.0000000000001351

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Randomized controlled trials demonstrate a significant decline in hospital admissions and length of stay following the initiation of clozapine in individuals with bipolar disorder and schizophrenia, along with an increase in quality-adjusted life years. The morbidity and mortality associated with clozapine-induced gastrointestinal hypomotility (CIGH) is greater than agranulocytosis. Despite this, we only have clozapine risk evaluation and mitigation strategies by the US Food and Drug Administration for white cell count monitoring, but none exists for CIGH. Our case highlights CIGH due to multiple factors and recommendations to prevent it and enhance clozapine compliance by conducting a thorough literature review.

引用

页数：3

共 2 条

[1] Fatalities Associated With Clozapine-Related Constipation and Bowel Obstruction: A Literature Review and Two Case Reports
Hibbard, Katharine R.
Propst, Arthur
Frank, Daniel E.
Wyse, Jonathan
PSYCHOSOMATICS, 2009, 50 (04) : 416 - 419
[2] Gastroenterologist's Recognition of Rare Adverse Drug Effect Prevents Further Harm in a Patient with Small Bowel Obstruction Due to Lisinopril: A Case Report and Literature Review
Rashad, Essam
El Yazal, Soukaina
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2024, 119 (10S): : S3093 - S3095

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