Phytochemical profile, antioxidant, and wound healing activities of Echium amoenum (Boraginaceae)

被引：0
作者：
Abd Haghighi, Mohammad Javad [1 ]
Azadbakht, Mohammad [1 ,2 ]
Habibi, Emran [1 ,2 ]
Vahedi, Lale [3 ]
Hosseinimehr, Seyed Jalal [4 ]
机构：
[1] Mazandaran Univ Med Sci, Fac Pharm, Dept Pharmacognosy, Sari, Iran
[2] Mazandaran Univ Med Sci, Med Plants Res Ctr, Sari, Iran
[3] Mazandaran Univ Med Sci, Fac Med, Dept Pathol, Sari, Iran
[4] Mazandaran Univ Med Sci, Fac Pharm, Dept Radiopharm, Sari, Iran
来源：
NATURAL PRODUCT RESEARCH | 2024年
关键词：
Iranian borage; wound healing; echium; naphthoquinone; ALKANNIN; SHIKONIN;
D O I：
10.1080/14786419.2024.2384079
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Natural products' inflammatory and antioxidant properties have crucial roles in tissue repair and regeneration. This study aimed to investigate HPLC analysis, antioxidant activity, and wound-healing effect of Echium amoenum (EA) on rats. The EA was analysed for the determination of shikonin a derivative of naphthoquinone. In the wound healing assessment, forty Wistar rats were divided into five groups that were receiving the cream base, normal saline (NS), 1% silver sulfadiazine (SSD), and 5 and 10% EA cream (EAC). Shikonin was found in the EA extract. The average wound area on the 10th day was 0.71 +/- 0.01, 0.86 +/- 0.13, 0.58 +/- 0.08, 0.53 +/- 0.03 and 0.43 +/- 0.04 cm2 for the cream base, NS, SSD, and 5 and 10% EAC, respectively. The collagen fibres were well formed and horizontally oriented in 5 and 10% EAC groups compared to other groups. EA cream was an effective treatment for wound healing in comparison with SSD.
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页数：7
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