[3] Karolinska Inst, Dept Oncol Pathol Onc Pat, Anna Stecksens Gata 30A,D2 04, S-17165 Solna, Sweden
[4] Karolinska Inst, Dept Mol Med & Surg MMK, Anna Stecksens Gata 53, S-17165 Solna, Sweden
来源:
JOURNAL OF PERSONALIZED MEDICINE
|
2024年
/
14卷
/
06期
关键词:
individualized medicine;
precision medicine;
personalized medicine;
stratified medicine;
translational cancer research;
cancer care;
oncology;
evidence-based medicine;
team science;
organization;
management;
scientific leadership;
CELL LUNG-CANCER;
PRECISION MEDICINE;
HEALTH-CARE;
TEAM SCIENCE;
TUMOR BOARD;
FUTURE;
CHALLENGES;
ONCOLOGY;
GENOMICS;
HETEROGENEITY;
D O I:
10.3390/jpm14060561
中图分类号:
R19 [保健组织与事业(卫生事业管理)];
学科分类号:
摘要:
The shift towards personalized cancer medicine (PCM) represents a significant transformation in cancer care, emphasizing tailored treatments based on the genetic understanding of cancer at the cellular level. This review draws on recent literature to explore key factors influencing PCM implementation, highlighting the role of innovative leadership, interdisciplinary collaboration, and coordinated funding and regulatory strategies. Success in PCM relies on overcoming challenges such as integrating diverse medical disciplines, securing sustainable investment for shared infrastructures, and navigating complex regulatory landscapes. Effective leadership is crucial for fostering a culture of innovation and teamwork, essential for translating complex biological insights into personalized treatment strategies. The transition to PCM necessitates not only organizational adaptation but also the development of new professional roles and training programs, underscoring the need for a multidisciplinary approach and the importance of team science in overcoming the limitations of traditional medical paradigms. The conclusion underscores that PCM's success hinges on creating collaborative environments that support innovation, adaptability, and shared vision among all stakeholders involved in cancer care.
机构:
Princess Margaret Canc Ctr, Div Med Oncol, Toronto, ON, Canada
Univ Toronto, Toronto, ON, CanadaPrincess Margaret Canc Ctr, Div Med Oncol, Toronto, ON, Canada
Tannock, Ian F.
Hickman, John A.
论文数: 0引用数: 0
h-index: 0
机构:
AGON Paris, Paris, FrancePrincess Margaret Canc Ctr, Div Med Oncol, Toronto, ON, Canada
机构:
George Emil Palade Univ Med Pharm Sci & Technol T, Dept Anesthesiol & Intens Care, Targu Mures 540139, RomaniaGeorge Emil Palade Univ Med Pharm Sci & Technol T, Dept Anesthesiol & Intens Care, Targu Mures 540139, Romania
Lazar, Alexandra Elena
Azamfirei, Leonard
论文数: 0引用数: 0
h-index: 0
机构:
George Emil Palade Univ Med Pharm Sci & Technol T, Dept Anesthesiol & Intens Care, Targu Mures 540139, RomaniaGeorge Emil Palade Univ Med Pharm Sci & Technol T, Dept Anesthesiol & Intens Care, Targu Mures 540139, Romania
机构:
United Arab Emirates Univ, Coll Informat Technol, Dept Comp Sci & Software Engn, Al Ain 15551, U Arab EmiratesUnited Arab Emirates Univ, Coll Informat Technol, Dept Comp Sci & Software Engn, Al Ain 15551, U Arab Emirates
Ghebrehiwet, Isaias
Zaki, Nazar
论文数: 0引用数: 0
h-index: 0
机构:
United Arab Emirates Univ, Coll Informat Technol, Dept Comp Sci & Software Engn, Al Ain 15551, U Arab EmiratesUnited Arab Emirates Univ, Coll Informat Technol, Dept Comp Sci & Software Engn, Al Ain 15551, U Arab Emirates
Zaki, Nazar
Damseh, Rafat
论文数: 0引用数: 0
h-index: 0
机构:
United Arab Emirates Univ, Coll Informat Technol, Dept Comp Sci & Software Engn, Al Ain 15551, U Arab EmiratesUnited Arab Emirates Univ, Coll Informat Technol, Dept Comp Sci & Software Engn, Al Ain 15551, U Arab Emirates
Damseh, Rafat
Mohamad, Mohd Saberi
论文数: 0引用数: 0
h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Genet & Genom, Hlth Data Sci Lab, Al Ain 15551, U Arab EmiratesUnited Arab Emirates Univ, Coll Informat Technol, Dept Comp Sci & Software Engn, Al Ain 15551, U Arab Emirates
机构:
Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R ChinaSichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Su, Miao
Zhang, Zhe
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R ChinaSichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Zhang, Zhe
Zhou, Li
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R ChinaSichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Zhou, Li
Han, Chao
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R ChinaSichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Han, Chao
Huang, Canhua
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R ChinaSichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Huang, Canhua
Nice, Edouard C.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, AustraliaSichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
机构:
UNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Sydney Childrens Hosp, Kids Canc Ctr, Randwick, NSW, AustraliaUNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Vetsch, J.
Wakefield, C. E.
论文数: 0引用数: 0
h-index: 0
机构:
UNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Sydney Childrens Hosp, Kids Canc Ctr, Randwick, NSW, AustraliaUNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Wakefield, C. E.
Techakesari, P.
论文数: 0引用数: 0
h-index: 0
机构:
UNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Sydney Childrens Hosp, Kids Canc Ctr, Randwick, NSW, AustraliaUNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Techakesari, P.
Warby, M.
论文数: 0引用数: 0
h-index: 0
机构:
Prince Wales Hosp, Dept Oncol & Haematol, Hereditary Canc Ctr, Randwick, NSW, AustraliaUNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Warby, M.
Ziegler, D. S.
论文数: 0引用数: 0
h-index: 0
机构:
UNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Sydney Childrens Hosp, Kids Canc Ctr, Randwick, NSW, AustraliaUNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Ziegler, D. S.
O'Brien, T. A.
论文数: 0引用数: 0
h-index: 0
机构:
UNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Sydney Childrens Hosp, Kids Canc Ctr, Randwick, NSW, AustraliaUNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
O'Brien, T. A.
Drinkwater, C.
论文数: 0引用数: 0
h-index: 0
机构:
Hudson Inst Med Res, Clayton, Vic, AustraliaUNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Drinkwater, C.
Neeman, N.
论文数: 0引用数: 0
h-index: 0
机构:
Hudson Inst Med Res, Clayton, Vic, AustraliaUNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia
Neeman, N.
Tucker, K.
论文数: 0引用数: 0
h-index: 0
机构:
Prince Wales Hosp, Dept Oncol & Haematol, Hereditary Canc Ctr, Randwick, NSW, Australia
Univ New South Wales, Prince Wales Clin Sch, Sydney, NSW, AustraliaUNSW Sydney, Sch Womens & Childrens Hlth, Kensington, NSW, Australia