The relativity analysis of hypoxia inducible factor-1α in pulmonary arterial hypertension (ascites syndrome) in broilers: a review

Ascites syndrome (AS) in broiler chickens, also known as pulmonary arterial hypertension (PAH), is a significant disease in the poultry industry. It is a nutritional metabolic disease that is closely associated with hypoxia-inducible factors and rapid growth. The rise in pulmonary artery pressure is a crucial characteristic of AS and is instrumental in its development. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is an active subunit of a key transcription factor in the oxygen-sensing pathway. HIF-1 alpha plays a vital role in oxygen homeostasis and the development of pulmonary hypertension. Studying the effects of HIF-1 alpha on pulmonary hypertension in humans or mammals, as well as ascites in broilers, can help us understand the pathogenesis of AS. Therefore, this review aims to (1) summarize the mechanism of HIF-1 alpha in the development of pulmonary hypertension, (2) provide theoretical significance in explaining the mechanism of HIF-1 alpha in the development of pulmonary arterial hypertension (ascites syndrome) in broilers, and (3) establish the correlation between HIF-1 alpha and pulmonary arterial hypertension (ascites syndrome) in broilers. HIGHLIGHTSExplains the hypoxic mechanism of HIF-1 alpha.Linking HIF-1 alpha to pulmonary hypertension in broilers.Explains the role of microRNAs in pulmonary arterial hypertension in broilers.