The multifaceted role of Wnt canonical signalling in neurogenesis, neuroinflammation, and hyperexcitability in mesial temporal lobe epilepsy

被引：4
作者：
Priya [1 ]
Yadav, Nitin [1 ]
Anand, Sneha [1 ]
Banerjee, Jyotirmoy [2 ]
Tripathi, Manjari [3 ]
Chandra, P. Sarat [4 ]
Dixit, Aparna Banerjee [1 ]
机构：
[1] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Delhi, India
[2] All India Inst Med Sci, Dept Biophys, New Delhi, India
[3] All India Inst Med Sci, Dept Neurol, New Delhi, India
[4] All India Inst Med Sci, Dept Neurosurg, New Delhi, India
来源：
NEUROPHARMACOLOGY | 2024年 / 251卷
关键词：
Wnt/beta-Catenin; Temporal lobe epilepsy; Hyperexcitability; Anti-seizure drugs; Therapeutic targets; Neuroinflammation; GRANULE CELL DISPERSION; BLOOD-BRAIN-BARRIER; MESSENGER-RNA LEVELS; DENTATE GYRUS; BETA-CATENIN; ADULT NEUROGENESIS; KAINIC ACID; SYNAPTIC DIFFERENTIATION; STIMULATES PROLIFERATION; HIPPOCAMPAL NEUROGENESIS;
D O I：
10.1016/j.neuropharm.2024.109942
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Epilepsy is a neurological disorder characterised by unprovoked, repetitive seizures caused by abnormal neuronal firing. The Wnt/ beta-Catenin signalling pathway is involved in seizure -induced neurogenesis, aberrant neurogenesis, neuroinflammation, and hyperexcitability associated with epileptic disorder. Wnt/ beta-Catenin signalling is crucial for early brain development processes including neuronal patterning, synapse formation, and Nmethyl- D -aspartate receptor (NMDAR) regulation. Disruption of molecular networks such as Wnt/ beta-catenin signalling in epilepsy could offer encouraging anti-epileptogenic targets. So, with a better understanding of the canonical Wnt/-Catenin pathway, we highlight in this review the important elements of Wnt/-Catenin signalling specifically in Mesial Temporal Lobe Epilepsy (MTLE) for potential therapeutic targets.
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页数：16
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