Performance of spleen stiffness measurement to rule out high-risk varices in patients with porto-sinusoidal vascular disorder

被引:7
作者
Moga, Lucile [1 ,2 ]
Paradis, Valerie [2 ,3 ]
Ferreira-Silva, Joel [4 ,5 ]
Gudavalli, Koushik [6 ]
Indulti, Federica [7 ]
Dajti, Elton [8 ,9 ]
Nicoara-Farcau, Oana [10 ,11 ,12 ]
Tosetti, Giulia [13 ]
Antonenko, Antonina [14 ]
Fodor, Andreea [10 ,11 ]
Vidal-Gonzalez, Judit [15 ]
Turco, Laura [16 ]
Capinha, Francisco [17 ]
Elkrief, Laure [18 ]
Monllor-Nunell, Teresa [19 ]
Goria, Odile [20 ]
Balcar, Lorenz [21 ]
Lannes, Adrien [22 ]
Mallet, Vincent [23 ]
Poujol-Robert, Armelle [24 ]
Thabut, Dominique [25 ,26 ]
Houssel-Debry, Pauline [27 ]
Wong, Yu Jun [28 ,29 ]
Ronot, Maxime [30 ]
Vilgrain, Valerie [30 ]
Rampally, Sai Prasanth [6 ]
Payance, Audrey [1 ,2 ]
Castera, Laurent [32 ,33 ]
Reiberger, Thomas [20 ]
Ferrusquia-Acosta, Jose [18 ]
Noronha Ferreira, Carlos [16 ]
Vitale, Giovanni [16 ]
Simon-Talero, Macarena [15 ]
Procopet, Bogdan [10 ]
Berzigotti, Annalisa [14 ]
Caccia, Riccardo [13 ]
Turon, Fanny [31 ]
Schepis, Filippo [7 ]
Ravaioli, Federico [8 ,9 ]
Colecchia, Antonio [7 ]
Valsan, Arun [6 ]
Macedo, Guilherme [4 ,5 ]
Plessier, Aurelie [1 ,2 ]
Rautou, Pierre-Emmanuel [1 ,2 ,32 ]
机构
[1] Hop Beaujon, AP HP, Ctr Reference Malad Vasc Foie, Serv Hepatol,DMU DIGEST,FILFOIE,ERN RARE LIVER, Clichy, France
[2] Univ Paris, Inserm, Ctr Rech Inflammat, UMR 1149, Paris, France
[3] Hop Beaujon, Dept Anat Pathol, Clichy, France
[4] Ctr Hosp & Univ Sao Joao, Gastroenterol Dept, Sao Joao, Portugal
[5] Univ Porto, Fac Med, Porto, Portugal
[6] Amrita Inst Med Sci, Dept Gastroenterol, Hepatol & Transplantat Unit, Kochi, India
[7] Univ Modena & Reggio Emilia, Univ Hosp Modena, CHIMOMO Dept, Gastroenterol Unit, Modena, Italy
[8] IRCCS Azienda Osped Univ Bologna, Div Internal Med Hepatobiliary & Immunoallerg Dis, Bologna, Italy
[9] Univ Bologna, Dept Med & Surg Sci DIMEC, Bologna, Italy
[10] Univ Med & Pharm Iuliu Hatieganu, Med Clin 3, Cluj Napoca, Romania
[11] Univ Med & Pharm Iuliu Hatieganu, Reg Inst Gastroenterol & Hepatol Prof Dr Octavian, Hepatol Dept, Cluj Napoca, Romania
[12] Univ Barcelona, Hosp Clin, Liver Unit, Hepat Hemodynam Dept,IDIBAPS, E-08036 Barcelona, Spain
[13] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Div Gastroenterol & Hepatol, Milan, Italy
[14] Univ Bern, Bern Univ Hosp, Dept Visceral Surg & Med, Inselspital, Bern, Switzerland
[15] Univ Autonoma Barcelona, Vall dHebron Univ Hosp, Vall dHebron Inst Res VHIR, Liver Unit,Digest Dis Dept,CIBERehd, Vall dHebron Barcelona Hosp Campus, Barcelona, Spain
[16] IRCCS Azienda Osped Univ Bologna, Internal Med Unit Treatment Severe Organ Failure, I-40138 Bologna, Italy
[17] Ctr Hosp Univ Lisboa Norte, Hosp Santa Maria, Serv Gastrenterol & Hepatol, Lisbon, Portugal
[18] CHRU Tours Hop Trousseau, Fac Medecine Tours, Serv Hepatogastroenterol, Tours, France
[19] Hosp Univ Parc Tauli, Inst Invest & Innovacio Parc Tauli i I3PT, Liver Unit, Sabadell, Spain
[20] Hop Charles Nicolle CHU Rouen, Serv Hepatogastroenterol & Oncol Digest, Rouen, France
[21] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Vienna, Austria
[22] CHU Angers, Hepatogastroenterol & Oncol Digest, Angers, France
[23] Univ Paris Cite, Assistance Publ Hop Paris, Serv Malad Foie, Grp Hosp Cochin Port Royal, Paris, France
[24] Hop St Antoine, Assistance Publ Hop Paris, Hepatol, Paris, France
[25] Hop Pitie Salpetrie`re, Assistance Publ Hop Paris, Hepatogastroenterol Dept, Liver Intens Care Unit, Paris, France
[26] Sorbonne Univ, Ctr Rech St Antoine, Inserm, UMR S 938, Paris, France
[27] Hop Pontchaillou CHU Rennes, Ctr Hepato Digest Malad Foie, Rennes, France
[28] SingHealth, Changi Gen Hosp, Dept Gastroenterol & Hepatol, Singapore, Singapore
[29] Duke NUS Med Sch, Singapore, Singapore
[30] Beaujon Hosp, GHU AP HP Nord Univ Paris Cite, Dept Radiol, Clichy, France
[31] IDIBAPS, Hosp Clin, Liver Unit, CIBERehd, Barcelona, Spain
[32] Hop Beaujon, AP HP, Serv Hepatol, 100 Blvd Gen Leclerc, F-92110 Clichy, France
[33] Univ Paris Cite, Ctr Rech Inflammat, Inserm, UMR 1149, Paris, France
关键词
porto-sinusoidal vascular disorder; high-risk varices; spleen stiffness measurement; portal hypertension; HYPERTENSION; ELASTOGRAPHY; CONSENSUS; CIRRHOSIS;
D O I
10.1097/HEP.0000000000001004
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Baveno VII consensus suggests that screening endoscopy can be spared in patients with compensated cirrhosis when spleen stiffness measurement (SSM) by vibration-controlled transient elastography (VCTE) is <= 40 kPa as they have a low probability of high-risk varices (HRV). Conversely, screening endoscopy is required in all patients with porto-sinusoidal vascular disorder (PSVD). This study aimed to evaluate the performance of SSM-VCTE to rule out HRV in patients with PSVD and signs of portal hypertension. Approach & results: We retrospectively included patients with PSVD, >= 1 sign of portal hypertension, without history of variceal bleeding, who underwent a SSM-VCTE within 2 years before or after an upper endoscopy in 21 VALDIG centers, divided into a derivation and a validation cohort. 154 patients were included in the derivation cohort; 43% had HRV. By multivariable logistic regression analysis, SSM-VCTE >40 kPa and serum bilirubin >= 1 mg/dL were associated with HRV. SSM-VCTE <= 40 kPa combined with bilirubin <1 mg/dL had a sensitivity of 96% to rule out HRV, and could spare 38% of screening endoscopies, with 4% of HRV missed, and a 95% negative predictive value (NPV). In the validation cohort, including 155 patients, SSM combined with bilirubin could spare 21% of screening endoscopies, with 4% of HRV missed and a 94% NPV. Conclusion: This study gathering a total of 309 PSVD patients showed that SSM-VCTE <= 40 kPa combined with bilirubin <1 mg/dL identifies patients with PSVD and portal hypertension with a probability of HRV <5%, in whom screening endoscopy can be spared.
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页数:33
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