Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches

被引：3

作者：

Gu, Guangjin ^{[1
,2
,3
]}

Yu, Huaqi ^{[1
]}

Zou, Huishuang ^{[1
]}

Kou, Wenjuan ^{[4
,5
]}

Zhang, Pingping ^{[1
]}

Gu, Guangjie ^{[6
]}

Lu, Jie ^{[1
]}

Shi, Weihan ^{[1
]}

Chu, Pengcheng ^{[1
]}

Zhang, Yaning ^{[1
]}

Sun, Guangwei ^{[1
]}

Shang, Jun ^{[1
,7
]}

机构：

[1] Linfen Peoples Hosp, Dept Orthoped, Affiliated Hosp 7, Shanxi Med Coll, Linfen 041000, Shanxi, Peoples R China

[2] Shandong Univ, Qilu Hosp, Dept Orthoped, Jinan 250033, Shandong, Peoples R China

[3] Shandong Univ, Shandong Univ Ctr Orthoped, Adv Med Res Inst, Jinan 250012, Shandong, Peoples R China

[4] Tianjin Med Univ, Sch Pharmaceut Sci, Tianjin Key Lab Technol Enabling Dev Clin Therapeu, Tianjin 300070, Peoples R China

[5] Tianjin Med Univ, Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China

[6] Nantong Univ, Xinglin Coll, Dept Med, Nantong 226008, Jiangsu, Peoples R China

[7] Shandong Univ, Dept Orthopaed, Hosp 2, Jinan 250033, Shandong, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2024年 / 29卷 / 06期

关键词：

spinal cord injury; pyroptosis; gasdermin D; inflammasome; NLRP3; NLRP3; INFLAMMASOME; NALP3; AUGMENTING AUTOPHAGY; AIM2; IMPROVES RECOVERY; ACTIVATION; CALCIUM; MECHANISMS; APOPTOSIS; TARGET;

D O I：

10.31083/j.fbl2906210

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Traumatic spinal cord injury (SCI) is a serious disease of the central nervous system. Aside from the limited intrinsic regenerative capacity of neurons, complex microenvironmental disturbances can also lead to further cellular damage and growth inhibition. Programmed cell death regulated by pyroptosis has an important role in the pathogenesis of SCI. While there has been a wealth of new knowledge regarding cellular pyroptosis, a detailed understanding of its role in SCI and possible therapeutic strategies is still lacking. This review summarizes current advances in the regulatory role of pyroptosis-regulated cell death and inflammasome components in the inhibitory microenvironment following SCI, as well as recent therapeutic advances.

引用

页数：16

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