The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes

被引：1
作者：
Carciero, Lorenzo [1 ]
Di Giuseppe, Gianfranco [1 ,2 ]
Di Piazza, Eleonora [2 ]
Parand, Erfan [2 ]
Soldovieri, Laura [1 ,2 ]
Ciccarelli, Gea [1 ,2 ]
Brunetti, Michela [1 ,2 ]
Gasbarrini, Antonio [2 ,3 ]
Nista, Enrico C. [3 ]
Pani, Giovambattista [1 ]
Pontecorvi, Alfredo [1 ,2 ]
Giaccari, Andrea [1 ,2 ]
Mezza, Teresa [2 ,3 ]
机构：
[1] Fdn Policlin Univ Gemelli IRCCS, Endocrinol & Diabetol Unit, Rome, Italy
[2] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, Rome, Italy
[3] Fdn Policlin Univ Gemelli IRCCS, CEMAD Digest Dis Ctr, Pancreas Unit, Internal Med & Gastroenterol Unit, Rome, Italy
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2024年 / 216卷
关键词：
Extracellular vesicles; Microvesicles; Exosomes; Type; 2; diabetes; Metabolic disease; Pancreatic islets; CELL-DERIVED MICROPARTICLES; ADIPOSE-TISSUE; INSULIN-RESISTANCE; IN-VITRO; EXOSOMES; MICROVESICLES; OBESITY; ANGIOGENESIS; PLATELET; STRESS;
D O I：
10.1016/j.diabres.2024.111837
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The pathogenesis of type 2 diabetes (T2D) involves dysfunction in multiple organs, including the liver, muscle, adipose tissue, and pancreas, leading to insulin resistance and beta cell failure. Recent studies highlight the significant role of extracellular vesicles (EVs) in mediating inter-organ communication in T2D. This review investigates the role of EVs, focusing on their presence and biological significance in human plasma and tissues affected by T2D. We explore specific EV cargo, such as miRNAs and proteins, which affect insulin signaling and glucose metabolism, emphasizing their potential as biomarkers. By highlighting the diagnostic and therapeutic potential of EVs, we aim to provide new insights into their role in early detection, disease monitoring, and innovative treatment strategies for T2D.
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页数：11
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