Extracellular Vesicles and Immune System Function: Exploring Novel Approaches to Colorectal Cancer Immunotherapy

被引：4
作者：
Biondi, Antonio [1 ]
Vacante, Marco [2 ]
Catania, Roberta [1 ]
Sangiorgio, Giuseppe [1 ,3 ]
机构：
[1] Univ Catania, Dept Gen Surg & Med Surg Specialties, Via Santa Sofia 78, I-95123 Catania, Italy
[2] ARNAS Garibaldi, Unit Internal Med Crit Area, Piazza Santa Maria Gesu 5, I-95124 Catania, Italy
[3] Univ Catania, Dept Biomed & Biotechnol Sci, Via Santa Sofia 97, I-95123 Catania, Italy
来源：
BIOMEDICINES | 2024年 / 12卷 / 07期
关键词：
extracellular vesicles; immunotherapy; colorectal cancer; DENDRITIC CELLS; B-CELLS; T-CELLS; EXOSOMES; MICROVESICLES; METASTASIS; BIOGENESIS; RELEASE; IDENTIFICATION; INFLAMMATION;
D O I：
10.3390/biomedicines12071473
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review explores the emerging role of extracellular vesicles (EVs) in modulating immune system function and their application in novel cancer immunotherapy strategies, with a focus on colorectal cancer (CRC). EVs, as carriers of bioactive molecules, have shown potential in enhancing immune responses and overcoming the limitations of traditional therapies. We discuss the biogenesis, types, and functional roles of immune cell-derived EVs, their interactions with cancer cells, and their implications in antitumor immunity. Challenges such as tumor heterogeneity and immune evasion are addressed, alongside the promising therapeutic prospects of EV-based strategies. This comprehensive analysis underscores the transformative potential of EVs in cancer treatment paradigms.
引用
收藏
页数：18
相关论文
共 177 条
[1]   An emerging interplay between extracellular vesicles and cytokines [J].
Aiello, Alessandra ;
Giannessi, Flavia ;
Percario, Zulema A. ;
Affabris, Eisabetta .
CYTOKINE & GROWTH FACTOR REVIEWS, 2020, 51 :49-60
[2]   Neutrophil-derived extracellular vesicles modulate the phenotype of naive human neutrophils [J].
Amjadi, Maya F. ;
Avner, Benjamin S. ;
Greenlee-Wacker, Mallary C. ;
Horswill, Alexander R. ;
Nauseef, William M. .
JOURNAL OF LEUKOCYTE BIOLOGY, 2021, 110 (05) :917-925
[3]   Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation [J].
Arya, Subhash B. ;
Chen, Song ;
Jordan-Javed, Fatima ;
Parent, Carole A. .
NATURE CELL BIOLOGY, 2022, 24 (07) :1019-+
[4]   Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly [J].
Atkin-Smith, Georgia K. ;
Miles, Mark A. ;
Tixeira, Rochelle ;
Lay, Fung T. ;
Duan, Mubing ;
Hawkins, Christine J. ;
Thanh Kha Phan ;
Paone, Stephanie ;
Mathivanan, Suresh ;
Hulett, Mark D. ;
Chen, Weisan ;
Poon, Ivan K. H. .
CELL REPORTS, 2019, 29 (07) :1821-+
[5]   Dynamic regulation of CD24 expression and release of CD24-containing microvesicles in immature B cells in response to CD24 engagement [J].
Ayre, D. Craig ;
Elstner, Marcus ;
Smith, Nicole C. ;
Moores, Emily S. ;
Hogan, Andrew M. ;
Christian, Sherri L. .
IMMUNOLOGY, 2015, 146 (02) :217-233
[6]   Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro-RNA 155 in Alcoholic Liver Disease [J].
Babuta, Mrigya ;
Furi, Istvan ;
Bala, Shashi ;
Bukong, Terence N. ;
Lowe, Patrick ;
Catalano, Donna ;
Calenda, Charles ;
Kodys, Karen ;
Szabo, Gyongyi .
HEPATOLOGY, 2019, 70 (06) :2123-2141
[7]   VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites [J].
Barman, Bahnisikha ;
Sung, Bong Hwan ;
Krystofiak, Evan ;
Ping, Jie ;
Ramirez, Marisol ;
Millis, Bryan ;
Allen, Ryan ;
Prasad, Nripesh ;
Chetyrkin, Sergei ;
Calcutt, M. Wade ;
Vickers, Kasey ;
Patton, James G. ;
Liu, Qi ;
Weaver, Alissa M. .
DEVELOPMENTAL CELL, 2022, 57 (08) :974-+
[8]   Chimeric Antigen Receptor Therapy for Cancer [J].
Barrett, David M. ;
Singh, Nathan ;
Porter, David L. ;
Grupp, Stephan A. ;
June, Carl H. .
ANNUAL REVIEW OF MEDICINE, VOL 65, 2014, 65 :333-347
[9]   Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo [J].
Bhatnagar, Sanchita ;
Shinagawa, Kazuhiko ;
Castellino, Francis J. ;
Schorey, Jeff Rey S. .
BLOOD, 2007, 110 (09) :3234-3244
[10]   Metabolic tagging of extracellular vesicles and development of enhanced extracellular vesicle based cancer vaccines [J].
Bhatta, Rimsha ;
Han, Joonsu ;
Liu, Yusheng ;
Bo, Yang ;
Lee, David ;
Zhou, Jiadiao ;
Wang, Yueji ;
Nelson, Erik Russell ;
Chen, Qian ;
Zhang, Xiaojia Shelly ;
Hassaneen, Wael ;
Wang, Hua .
NATURE COMMUNICATIONS, 2023, 14 (01)
12345678910