Extracellular Vesicles and Immune System Function: Exploring Novel Approaches to Colorectal Cancer Immunotherapy

被引：2
作者：
Biondi, Antonio [1 ]
Vacante, Marco [2 ]
Catania, Roberta [1 ]
Sangiorgio, Giuseppe [1 ,3 ]
机构：
[1] Univ Catania, Dept Gen Surg & Med Surg Specialties, Via Santa Sofia 78, I-95123 Catania, Italy
[2] ARNAS Garibaldi, Unit Internal Med Crit Area, Piazza Santa Maria Gesu 5, I-95124 Catania, Italy
[3] Univ Catania, Dept Biomed & Biotechnol Sci, Via Santa Sofia 97, I-95123 Catania, Italy
来源：
BIOMEDICINES | 2024年 / 12卷 / 07期
关键词：
extracellular vesicles; immunotherapy; colorectal cancer; DENDRITIC CELLS; B-CELLS; T-CELLS; EXOSOMES; MICROVESICLES; METASTASIS; BIOGENESIS; RELEASE; IDENTIFICATION; INFLAMMATION;
D O I：
10.3390/biomedicines12071473
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review explores the emerging role of extracellular vesicles (EVs) in modulating immune system function and their application in novel cancer immunotherapy strategies, with a focus on colorectal cancer (CRC). EVs, as carriers of bioactive molecules, have shown potential in enhancing immune responses and overcoming the limitations of traditional therapies. We discuss the biogenesis, types, and functional roles of immune cell-derived EVs, their interactions with cancer cells, and their implications in antitumor immunity. Challenges such as tumor heterogeneity and immune evasion are addressed, alongside the promising therapeutic prospects of EV-based strategies. This comprehensive analysis underscores the transformative potential of EVs in cancer treatment paradigms.
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页数：18
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共 177 条
  • [1] An emerging interplay between extracellular vesicles and cytokines
    Aiello, Alessandra
    Giannessi, Flavia
    Percario, Zulema A.
    Affabris, Eisabetta
    [J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2020, 51 : 49 - 60
  • [2] Neutrophil-derived extracellular vesicles modulate the phenotype of naive human neutrophils
    Amjadi, Maya F.
    Avner, Benjamin S.
    Greenlee-Wacker, Mallary C.
    Horswill, Alexander R.
    Nauseef, William M.
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2021, 110 (05) : 917 - 925
  • [3] Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation
    Arya, Subhash B.
    Chen, Song
    Jordan-Javed, Fatima
    Parent, Carole A.
    [J]. NATURE CELL BIOLOGY, 2022, 24 (07) : 1019 - +
  • [4] Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly
    Atkin-Smith, Georgia K.
    Miles, Mark A.
    Tixeira, Rochelle
    Lay, Fung T.
    Duan, Mubing
    Hawkins, Christine J.
    Thanh Kha Phan
    Paone, Stephanie
    Mathivanan, Suresh
    Hulett, Mark D.
    Chen, Weisan
    Poon, Ivan K. H.
    [J]. CELL REPORTS, 2019, 29 (07): : 1821 - +
  • [5] Dynamic regulation of CD24 expression and release of CD24-containing microvesicles in immature B cells in response to CD24 engagement
    Ayre, D. Craig
    Elstner, Marcus
    Smith, Nicole C.
    Moores, Emily S.
    Hogan, Andrew M.
    Christian, Sherri L.
    [J]. IMMUNOLOGY, 2015, 146 (02) : 217 - 233
  • [6] Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro-RNA 155 in Alcoholic Liver Disease
    Babuta, Mrigya
    Furi, Istvan
    Bala, Shashi
    Bukong, Terence N.
    Lowe, Patrick
    Catalano, Donna
    Calenda, Charles
    Kodys, Karen
    Szabo, Gyongyi
    [J]. HEPATOLOGY, 2019, 70 (06) : 2123 - 2141
  • [7] VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites
    Barman, Bahnisikha
    Sung, Bong Hwan
    Krystofiak, Evan
    Ping, Jie
    Ramirez, Marisol
    Millis, Bryan
    Allen, Ryan
    Prasad, Nripesh
    Chetyrkin, Sergei
    Calcutt, M. Wade
    Vickers, Kasey
    Patton, James G.
    Liu, Qi
    Weaver, Alissa M.
    [J]. DEVELOPMENTAL CELL, 2022, 57 (08) : 974 - +
  • [8] Chimeric Antigen Receptor Therapy for Cancer
    Barrett, David M.
    Singh, Nathan
    Porter, David L.
    Grupp, Stephan A.
    June, Carl H.
    [J]. ANNUAL REVIEW OF MEDICINE, VOL 65, 2014, 65 : 333 - 347
  • [9] Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo
    Bhatnagar, Sanchita
    Shinagawa, Kazuhiko
    Castellino, Francis J.
    Schorey, Jeff Rey S.
    [J]. BLOOD, 2007, 110 (09) : 3234 - 3244
  • [10] Metabolic tagging of extracellular vesicles and development of enhanced extracellular vesicle based cancer vaccines
    Bhatta, Rimsha
    Han, Joonsu
    Liu, Yusheng
    Bo, Yang
    Lee, David
    Zhou, Jiadiao
    Wang, Yueji
    Nelson, Erik Russell
    Chen, Qian
    Zhang, Xiaojia Shelly
    Hassaneen, Wael
    Wang, Hua
    [J]. NATURE COMMUNICATIONS, 2023, 14 (01)
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