Hepatitis B virus X protein and TGF-β: partners in the carcinogenic journey of hepatocellular carcinoma

被引：4
作者：
Yan, Wei [1 ,2 ,3 ]
Rao, Dean [1 ,2 ,3 ]
Fan, Feimu [1 ,2 ,3 ]
Liang, Huifang [1 ,2 ,3 ,4 ]
Zhang, Zunyi [1 ,2 ,3 ]
Dong, Hanhua [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Wuhan, Hubei, Peoples R China
[2] Hubei Key Lab Hepatopancreatobiliary Dis, Wuhan, Hubei, Peoples R China
[3] Hubei Prov Clin Med Res Ctr Hepat Surg, Wuhan, Hubei, Peoples R China
[4] Chinese Acad Med Sci, Key Lab Organ Transplantat, Minist Educ, Wuhan, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
基金：
中国国家自然科学基金;
关键词：
HBx protein; hepatitis B virus; TGF-beta signaling; hepatocellular carcinoma; tumor suppressor; pro-tumorigenic; GROWTH-FACTOR-BETA; MEDIATED TRANSCRIPTIONAL REPRESSION; SIGNAL-TRANSDUCTION PATHWAYS; INDUCED-APOPTOSIS; UP-REGULATION; C-MYC; TUMOR-SUPPRESSION; CHRONIC INFLAMMATION; DOWN-REGULATION; SMC5/6; COMPLEX;
D O I：
10.3389/fonc.2024.1407434
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatitis B infection is substantially associated with the development of liver cancer globally, with the prevalence of hepatocellular carcinoma (HCC) cases exceeding 50%. Hepatitis B virus (HBV) encodes the Hepatitis B virus X (HBx) protein, a pleiotropic regulatory protein necessary for the transcription of the HBV covalently closed circular DNA (cccDNA) microchromosome. In previous studies, HBV-associated HCC was revealed to be affected by HBx in multiple signaling pathways, resulting in genetic mutations and epigenetic modifications in proto-oncogenes and tumor suppressor genes. In addition, transforming growth factor-beta (TGF-beta) has dichotomous potentials at various phases of malignancy as it is a crucial signaling pathway that regulates multiple cellular and physiological processes. In early HCC, TGF-beta has a significant antitumor effect, whereas in advanced HCC, it promotes malignant progression. TGF-beta interacts with the HBx protein in HCC, regulating the pathogenesis of HCC. This review summarizes the respective and combined functions of HBx and TGB-beta in HCC occurrence and development.
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页数：19
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