Design, stereoselective synthesis, and antitumoral activity of combretastatin A-4 analogs

被引：1

作者：

da Silva, Wilson P. ^{[1
]}

Caiana, Robrigo R. A. ^{[2
]}

Barros, Maria E. S. B. ^{[3
]}

Freitas, Juliano C. R. ^{[4
]}

da Silva, Paulo B. N. ^{[5
]}

Milita, Gardenia G. C. ^{[5
]}

Oliveira, Roberta A. ^{[1
]}

Menezes, Paulo H. ^{[1
]}

机构：

[1] Univ Fed Pernambuco, Dept Quim Fundamental, CCEN, Recife, PE, Brazil

[2] Univ Fed Pernambuco, Dept Antibiot CB, Recife, PE, Brazil

[3] Univ Fed Alagoas, Inst Quim & Biotecnol, Maceio, AL, Brazil

[4] Univ Fed Campina Grande, Ctr Educ & Saude, Cuite, PB, Brazil

[5] Univ Fed Pernambuco, Dept de Fisiol & Farmacol CB, Recife, PE, Brazil

来源：

RESULTS IN CHEMISTRY | 2024年 / 7卷

关键词：

Combretastatin A-4; Antitumoral; Potassium organotrifluoroborates; Vinyl tellurides; Molecular docking; CROSS-COUPLING REACTIONS; ANTINEOPLASTIC AGENTS; CHEMISTRY; GROWTH; POTENT; ACIDS;

D O I：

10.1016/j.rechem.2024.101539

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Combretastatin A-4 (CA-4) is a microtubule targeting agent, and it has a great advantage when compared to other compounds with a similar mechanism of action, such as vinca alkaloids, colchicine, podophillotoxin, and paclitaxel: its simpler structure. In this work, the stereoselective synthesis and antiproliferative activity of stable CA-4 analogs, obtained from the cross-coupling reaction between vinyl tellurides and potassium aryltrifluoroborates is described. The method is simple, fast, and general, allowing further applications for the synthesis of more complex compounds.

引用

页数：9

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