Very Long-term Survivorship in Pediatric DIPG: Case Report and Review of the Literature

被引：1

作者：

Dimentberg, Evan ^{[1
]}

Marceau, Marie-Pier ^{[1
]}

Lachance, Alexandre ^{[1
]}

Bergeron-Gravel, Samuel ^{[2
]}

Saikali, Stephan ^{[3
]}

Crevier, Louis ^{[4
]}

Bourget, Catherine ^{[5
]}

Hawkins, Cynthia ^{[6
]}

Jabado, Nada ^{[7
]}

Giannakouros, Panagiota ^{[8
]}

Renzi, Samuele ^{[8
]}

Larouche, Valerie ^{[8
,9
]}

机构：

[1] Univ Laval, Fac Med, Quebec City, PQ, Canada

[2] Univ Laval, Div Radiat Oncol, CHU Quebec, Quebec City, PQ, Canada

[3] Univ Laval, Dept Mol Biol Med Biol & Pathol, CHU Quebec, Quebec City, PQ, Canada

[4] Univ Laval, Dept Surg, Div Neurosurg, CHU Quebec, Quebec City, PQ, Canada

[5] Univ Laval, Dept Radiol, CHU Quebec, Quebec City, PQ, Canada

[6] Univ Laval, Dept Pediat, Div Hemato Oncol, CHU Quebec, Quebec City, PQ, Canada

[7] Hosp Sick Children, Dept Lab Med & Pathobiol Neuropathol, Toronto, ON, Canada

[8] Montreal Childrens Hosp, Dept Pediat, Div Hemato Oncol, Montreal, PQ, Canada

[9] Univ Lavalx, CHU Quebec, 2705 Blvd Laurier, Ste Foy, PQ G1V 4G2, Canada

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2024年 / 46卷 / 04期

关键词：

very long-term survivorship; diffuse intrinsic pontine glioma (DIPG); case report; INTRINSIC PONTINE GLIOMA; DIFFUSE; PROGRESSION; SURVIVAL; FEATURES; CHILDREN;

D O I：

10.1097/MPH.0000000000002853

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diffuse intrinsic pontine gliomas are lethal tumors with a prognosis generally less than 1 year. Few cases of survivors of 5 years or more have been reported. This case report highlights the journey of a 9.5-year survivor who underwent 3 rounds of focal radiotherapy; she experienced 6 years of progression-free survival following the first round but ultimately succumbed to her disease. An autopsy revealed a favorable IDH1 mutation and the absence of H3K27M. This case reiterates the importance of extensive molecular analyses in diffuse intrinsic pontine gliomas and explores the potential benefit of re-irradiation in patients with positive responses and long periods of remission.

引用

页码：211 / 215

页数：5

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