miRNA-21, an Important Regulator of Autoimmune Diseases

被引：0

作者：

Tofigh, Roghayeh ^{[1
]}

Safaralizadeh, Reza ^{[1
]}

Hosseinpourfeizi, Mohammadali ^{[1
]}

Hemmat, Nima ^{[2
]}

Baradaran, Behzad ^{[2
]}

机构：

[1] Univ Tabriz, Fac Nat Sci, Dept Anim Biol, Tabriz, Iran

[2] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

来源：

CURRENT MOLECULAR MEDICINE | 2024年

关键词：

miRNA-21; autoimmune disease; immunomodulation; autoimmunity; SLE; IBD; RA; Type; 1; diabetes; MS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; TYPE-1; DIABETES-MELLITUS; MICRORNA EXPRESSION PROFILES; PRIMARY BILIARY CHOLANGITIS; CD4(+) T-CELLS; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; IMMUNE-SYSTEM; DOWN-REGULATION; MIR-21;

D O I：

10.2174/0115665240290075240514164601

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

miRNA-21 is regarded as both an abundant and highly conserved member of the microRNA (miRNA) family. It is expressed in virtually every cell and is responsible for critical regulatory actions that are important in health and disease. This microRNA has been shown to potentially have a role in the pathogenesis of several immune-related disorders, including autoimmune diseases, such as Multiple sclerosis and systemic lupus erythematosus, as two prominent examples of diseases that might be involved. In the current research, we looked at the role of miRNA-21, regarded as one of the most significant pathogenic miRNAs with a role in the development of autoimmune illness.

引用

页数：13

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