Sex differences in Huntington's disease from a neuroinflammation perspective

被引：1

作者：

Risby-Jones, Grace ^{[1
]}

Lee, John D. ^{[1
]}

Woodruff, Trent M. ^{[1
,2
]}

Fung, Jenny N. ^{[1
]}

机构：

[1] Univ Queensland, Sch Biomed Sci, St Lucia, Qld, Australia

[2] Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia

来源：

FRONTIERS IN NEUROLOGY | 2024年 / 15卷

基金：

英国医学研究理事会;

关键词：

Huntington (disease); neuroinflammation; sex difference; microglia; oligodendrocytes (OLs); astrocytes; 17; BETA-ESTRADIOL; PLASMA TESTOSTERONE; ASTROCYTE; THERAPY; FEMALE; OLIGODENDROCYTES; TETRABENAZINE; MYELINATION; FEATURES; DEFICITS;

D O I：

10.3389/fneur.2024.1384480

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Huntington's disease (HD) is a debilitating neurodegenerative condition characterized by motor, cognitive and psychiatric abnormalities. Immune dysregulation, prominently featuring increased immune activity, plays a significant role in HD pathogenesis. In addition to the central nervous system (CNS), systemic innate immune activation and inflammation are observed in HD patients, exacerbating the effects of the Huntingtin (HTT) gene mutation. Recent attention to sex differences in HD symptom severity underscores the need to consider gender as a biological variable in neurodegenerative disease research. Understanding sex-specific immune responses holds promise for elucidating HD pathophysiology and informing targeted treatment strategies to mitigate cognitive and functional decline. This perspective will highlight the importance of investigating gender influence in HD, particularly focusing on sex-specific immune responses predisposing individuals to disease.

引用

页数：7

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