Metal-Organic Frameworks-Based Nanoplatform for Treatment of Breast Cancer

被引：7
作者：
Li, Yi [1 ]
Sun, Huilin [1 ]
Yang, Chenxue [1 ,3 ]
Yan, Zihui [1 ]
Ge, Jing-Yuan [2 ]
Wang, Jianhao [1 ]
Chen, Zhongyan [2 ]
Qiu, Lin [1 ]
Bai, Yang [1 ]
机构：
[1] Changzhou Univ, Sch Pharm, Changzhou 213164, Peoples R China
[2] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China
[3] Changzhou Univ, Hua Loogeng Coll, Changzhou 213164, Peoples R China
来源：
ACS APPLIED NANO MATERIALS | 2024年 / 7卷 / 09期
基金：
中国国家自然科学基金;
关键词：
metal-organic frameworks; drug delivery; controlled release; antitumor; doxorubicin; PH; NANOPARTICLES; CODELIVERY; THERAPY; RELEASE; DESIGN; SYSTEM;
D O I：
10.1021/acsanm.4c00984
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Nanoscaled metal-organic frameworks (MOFs) have great prospects in drug delivery. As a unique architecture, MOF-on-MOF has emerged as a promising strategy to enhance drug loading and release efficacy. Herein, a ZIF-8-on-ZIF-8 nanoplatform has been fabricated via the MOF-on-MOF strategy for doxorubicin (DOX) loading, resulting in a core-shell hierarchical nanostructure (DOX@ZIF-8-on-ZIF-8, DZZ). This unique nanoplatform exhibited pH and GSH dual-responsive DOX-releasing behavior, which are features of the tumor microenvironment (TME). Compared to monolayer DOX-encapsulated monolayer ZIF-8 (DOX@ZIF-8, DZ), DZZ can significantly increase the drug loading efficiency (DLE) by 56-fold, increase drug encapsulation efficiency (DEE) by 25-fold, enhance the penetration depth of DOX, and improve the selective inhibition on breast cancer 4T1 cells both in vitro and in vivo. Such a ZIF-on-ZIF nanoplatform provides an efficient strategy for tumor-targeted drug delivery and breast cancer treatments.
引用
收藏
页码：10532 / 10542
页数：11
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