Prediction error determines how memories are organized in the brain

被引:2
|
作者
Kennedy, Nicholas G. W. [1 ]
Lee, Jessica C. [1 ,2 ]
Killcross, Simon [1 ]
Westbrook, R. Fred [1 ]
Holmes, Nathan M. [1 ]
机构
[1] Univ New South Wales, Sch Psychol, Sydney, Australia
[2] Univ Sydney, Sch Psychol, Sydney, Australia
来源
ELIFE | 2024年 / 13卷
基金
澳大利亚研究理事会;
关键词
prediction error; fear; learning; memory; extinction; latent state; EXTINCTION; CONTEXT; RESPONSES; NOVELTY; SLOW;
D O I
10.7554/eLife.95849
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
How is new information organized in memory? According to latent state theories, this is determined by the level of surprise, or prediction error, generated by the new information: a small prediction error leads to the updating of existing memory, large prediction error leads to encoding of a new memory. We tested this idea using a protocol in which rats were first conditioned to fear a stimulus paired with shock. The stimulus was then gradually extinguished by progressively reducing the shock intensity until the stimulus was presented alone. Consistent with latent state theories, this gradual extinction protocol (small prediction errors) was better than standard extinction (large prediction errors) in producing long-term suppression of fear responses, and the benefit of gradual extinction was due to updating of the conditioning memory with information about extinction. Thus, prediction error determines how new information is organized in memory, and latent state theories adequately describe the ways in which this occurs.
引用
收藏
页数:35
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