Development of Non-Invasive Biosensors for Neonatal Jaundice Detection: A Review

被引:2
作者
Hazarika, Chandan Jyoti [1 ]
Borah, Alee [1 ]
Gogoi, Poly [1 ]
Ramchiary, Shrimanta S. [1 ]
Daurai, Bethuel [1 ]
Gogoi, Manashjit [1 ]
Saikia, Manob Jyoti [2 ]
机构
[1] North Eastern Hill Univ, Dept Biomed Engn, Shillong 793022, Meghalaya, India
[2] Univ North Florida, Dept Elect Engn, Jacksonville, FL 32224 USA
来源
BIOSENSORS-BASEL | 2024年 / 14卷 / 05期
关键词
neonatal jaundice; non-invasive; bilirubin; biosensor; biomarkers; BILIRUBIN OXIDASE; MECHANISM; ALBUMIN; BLOOD; FILM;
D O I
10.3390/bios14050254
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
One of the most common problems many babies encounter is neonatal jaundice. The symptoms are yellowing of the skin or eyes because of bilirubin (from above 2.0 to 2.5 mg/dL in the blood). If left untreated, it can lead to serious neurological complications. Traditionally, jaundice detection has relied on invasive blood tests, but developing non-invasive biosensors has provided an alternative approach. This systematic review aims to assess the advancement of these biosensors. This review discusses the many known invasive and non-invasive diagnostic modalities for detecting neonatal jaundice and their limitations. It also notes that the recent research and development on non-invasive biosensors for neonatal jaundice diagnosis is still in its early stages, with the majority of investigations being in vitro or at the pre-clinical level. Non-invasive biosensors could revolutionize neonatal jaundice detection; however, a number of issues still need to be solved before this can happen. These consist of in-depth validation studies, affordable and user-friendly gadgets, and regulatory authority approval. To create biosensors that meet regulatory requirements, additional research is required to make them more precise and affordable.
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页数:15
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