Development of Non-Invasive Biosensors for Neonatal Jaundice Detection: A Review

被引:2
作者
Hazarika, Chandan Jyoti [1 ]
Borah, Alee [1 ]
Gogoi, Poly [1 ]
Ramchiary, Shrimanta S. [1 ]
Daurai, Bethuel [1 ]
Gogoi, Manashjit [1 ]
Saikia, Manob Jyoti [2 ]
机构
[1] North Eastern Hill Univ, Dept Biomed Engn, Shillong 793022, Meghalaya, India
[2] Univ North Florida, Dept Elect Engn, Jacksonville, FL 32224 USA
来源
BIOSENSORS-BASEL | 2024年 / 14卷 / 05期
关键词
neonatal jaundice; non-invasive; bilirubin; biosensor; biomarkers; BILIRUBIN OXIDASE; MECHANISM; ALBUMIN; BLOOD; FILM;
D O I
10.3390/bios14050254
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
One of the most common problems many babies encounter is neonatal jaundice. The symptoms are yellowing of the skin or eyes because of bilirubin (from above 2.0 to 2.5 mg/dL in the blood). If left untreated, it can lead to serious neurological complications. Traditionally, jaundice detection has relied on invasive blood tests, but developing non-invasive biosensors has provided an alternative approach. This systematic review aims to assess the advancement of these biosensors. This review discusses the many known invasive and non-invasive diagnostic modalities for detecting neonatal jaundice and their limitations. It also notes that the recent research and development on non-invasive biosensors for neonatal jaundice diagnosis is still in its early stages, with the majority of investigations being in vitro or at the pre-clinical level. Non-invasive biosensors could revolutionize neonatal jaundice detection; however, a number of issues still need to be solved before this can happen. These consist of in-depth validation studies, affordable and user-friendly gadgets, and regulatory authority approval. To create biosensors that meet regulatory requirements, additional research is required to make them more precise and affordable.
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页数:15
相关论文
共 78 条
[1]  
Abdulrazzak AY., 2024, BioMedInformatics, V4, P623
[2]   Demystifying non-invasive approaches for screening jaundice in low resource settings: a review [J].
Abiha, Umme ;
Banerjee, Dip Sankar ;
Mandal, Saptarshi .
FRONTIERS IN PEDIATRICS, 2023, 11
[3]  
Al Sampath Kumar K.P., 2010, Res. (T. Ph. Res.), P4
[4]   Neonatal Jaundice Diagnosis Using a Smartphone Camera Based on Eye, Skin, and Fused Features with Transfer Learning [J].
Althnian, Alhanoof ;
Almanea, Nada ;
Aloboud, Nourah .
SENSORS, 2021, 21 (21)
[5]   Electrochemical Sensor for Bilirubin Detection Using Paper-Based Screen-Printed Electrodes Functionalized with Silver Nanoparticles [J].
Anzar, Nigar ;
Suleman, Shariq ;
Kumar, Rocky ;
Rawal, Rachna ;
Pundir, Chandra Shekhar ;
Pilloton, Roberto ;
Narang, Jagriti .
MICROMACHINES, 2022, 13 (11)
[6]   Determinants of Neonatal Jaundice among Neonates Admitted to Neonatal Intensive Care Unit in Public General Hospitals of Central Zone, Tigray, Northern Ethiopia, 2019: a Case-Control Study [J].
Asefa, Guesh Gebreayezgi ;
Gebrewahid, Teklay Guesh ;
Nuguse, Hailemariam ;
Gebremichael, Mengistu Welday ;
Birhane, Merhawi ;
Zereabruk, Kidane ;
Zemicheal, Teklewoini Mariye ;
Hailay, Abrha ;
Abrha, Woldu Aberhe ;
Hadera, Surafel Aregawi ;
Hailu, Areaya Gebreegzabiher ;
Beyene, Brhane Hagos ;
Dagnazgi, Ebud Ayele ;
Tekulu, Fsaha Gebretsadkan ;
Welay, FissahaTekulu .
BIOMED RESEARCH INTERNATIONAL, 2020, 2020
[7]   Modified Kramer's versus Kramer's Method for Clinical Assessment of Jaundice in Term and Near-Term Neonates [J].
Bansal, Shivam ;
Kumar, Vivek ;
Sharma, Akash ;
Sankar, M. J. ;
Thukral, Anu ;
Verma, Ankit ;
Agarwal, Ramesh .
INDIAN JOURNAL OF PEDIATRICS, 2025, 92 (04) :351-357
[8]   Construction of an amperometric bilirubin biosensor based on covalent immobilization of bilirubin oxidase onto zirconia coated silica nanoparticles/chitosan hybrid film [J].
Batra, Bhawna ;
Lata, Suman ;
Sunny ;
Rana, J. S. ;
Pundir, Chandra Shekhar .
BIOSENSORS & BIOELECTRONICS, 2013, 44 :64-69
[9]   Paper-based potentiometric sensing of free bilirubin in blood serum [J].
Bell, Jeffrey G. ;
Mousavi, Maral P. S. ;
Abd El-Rahmana, Mohamed K. ;
Tan, Edward K. W. ;
Homer-Vanniasinkam, Shervanthi ;
Whitesides, George M. .
BIOSENSORS & BIOELECTRONICS, 2019, 126 :115-121
[10]  
Bernaldo Adélia Jeha Nasser, 2004, Sao Paulo Med. J., V122, P99, DOI 10.1590/S1516-31802004000300005