Objective: My objective was to summarize 16 original research manuscripts and 1 perspectives and commentary contribution that were submitted, peer reviewed, and accepted in this Special Issue on liver abscesses in cattle. Materials and Methods: A summary of key points made in the Special Issue articles is provided. Additional conclusions and thoughts about future directions of research to address liver abscesses (LA) in cattle are offered. Results and Discussion: This Special Issue represents the current understanding of the etiology, blood chemistry biomarkers, dietary and management strategies, and mitigation strategies for LA in cattle used in the feedlot industry throughout the United States and Canada. Seventeen articles from researchers and industry professionals studying LA in cattle are included, with studies ranging from practical dietary intervention strategies to experiments designed to understand the mode of action and the etiology of LA development. Implications and Applications: Liver abscess disease is a multifactorial, polymicrobial disease that affects multiple organ systems within the body, reflecting complex interactions among the host, environment, and pathogens. The pathogenesis of this disease needs to be further examined, and basic and applied research approaches should be employed to advance our understanding of liver abscesses in cattle.
