A Cerebellar Tumor-to-Tumor Metastasis in a Patient With Von Hippel-Lindau Disease

被引：0
作者：
Wang, Tengfei [1 ]
Liu, Lina [1 ]
Rampisela, Debby [1 ]
Dong, Xiuhua [1 ]
Keith, Kristin Alexndria [2 ]
Benardete, Ethan A. [2 ]
Shan, Frank Y. [1 ,2 ]
机构：
[1] Baylor Scott & White Hlth, Dept Pathol, Temple, TX USA
[2] Baylor Scott & White Hlth, Dept Neurosurg, Temple, TX USA
来源：
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2024年 / 32卷 / 05期
关键词：
Tumor-to-tumor metastasis; von Hippel-Lindau disease; ccRCC; hemangioblastoma; molecular-determined anatomic preference; RENAL-CELL-CARCINOMA; SUPPRESSOR GENE; HEMANGIOBLASTOMA; EXPRESSION; HYPOXIA; CHROMOSOME-3; LIGAND; RARE;
D O I：
10.1097/PAI.0000000000001197
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Tumor-to-tumor metastasis in the central nerve system is uncommon in our routine practice. Most reports include metastatic breast cancer into meningioma. Here we report a metastatic clear cell renal cell carcinoma (ccRCC) into a cerebellar hemangioblastoma in a patient with von Hippel-Lindau (VHL) disease. Imaging cannot distinguish metastatic ccRCC from primary cerebellar hemangioblastoma. Immuno-molecular studies are proven to be diagnostic. We also reviewed previously documented tumor-to-tumor metastasis of ccRCC to cerebellar hemangioblastoma in VHL disease. Lastly, we discussed potential mechanisms involved in the metastasis of ccRCC to hemangioblastoma in the cerebellum in patients with VHL.
引用
收藏
页码：244 / 248
页数：5
相关论文
共 40 条
[11]   Metastasis of renal cell carcinoma to central nervous system hemangioblastoma in two patients with von Hippel-Lindau disease [J].
Hamazaki, S ;
Nakashima, H ;
Matsumoto, K ;
Taguchi, K ;
Okada, S .
PATHOLOGY INTERNATIONAL, 2001, 51 (12) :948-953
[12]   Perfusion Dynamic Susceptibility Contrast and Dynamic Contrast-Enhanced MR Imaging [J].
Ibrahim, Mohannad ;
Ul Ghazi, Talha ;
Bapuraj, Jayapalli Rajiv ;
Srinivasan, Ashok .
MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA, 2021, 29 (04) :515-526
[13]   Expression of hypoxia-lnducible cell-surface transmembrane carbonic anhydrases in human cancer [J].
Ivanov, S ;
Liao, SY ;
Ivanova, A ;
Danilkovitch-Miagkova, A ;
Tarasova, N ;
Weirich, G ;
Merrill, MJ ;
Proescholdt, MA ;
Oldfield, EH ;
Lee, J ;
Zavada, J ;
Waheed, A ;
Sly, W ;
Lerman, MI ;
Stanbridge, EJ .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (03) :905-919
[14]   METASTASIS OF A RENAL-CARCINOMA TO A CEREBELLAR HEMANGIOBLASTOMA IN A CASE OF VONHIPPEL-LINDAU DISEASE [J].
JAMJOOM, A ;
KANE, N ;
NICOLL, J .
NEUROSURGICAL REVIEW, 1992, 15 (03) :231-234
[15]   Metastases to hemangioblastomas in von Hippel-Lindau disease [J].
Jarrell, S. Taylor ;
Vortmeyer, Alexander O. ;
Linehan, W. Marston ;
Oldfield, Edward H. ;
Lonser, Russell R. .
JOURNAL OF NEUROSURGERY, 2006, 105 (02) :256-263
[16]  
KANNO H, 1994, CANCER RES, V54, P4845
[17]   Loss of Von Hippel-Lindau (VHL) Tumor Suppressor Gene Function: VHL-HIF Pathway and Advances in Treatments for Metastatic Renal Cell Carcinoma (RCC) [J].
Kim, Hyunho ;
Shim, Byoung Yong ;
Lee, Seung-Ju ;
Lee, Ji Youl ;
Lee, Hyo-Jin ;
Kim, In-Ho .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (18)
[18]   Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma:: Relationship to clinicopathological parameters [J].
Kondo, K ;
Yao, M ;
Yoshida, M ;
Kishida, T ;
Shuin, T ;
Miura, T ;
Moriyama, M ;
Kobayashi, K ;
Sakai, N ;
Kaneko, S ;
Kawakami, S ;
Baba, M ;
Nakaigawa, N ;
Nagashima, Y ;
Nakatani, Y ;
Hosaka, M .
GENES CHROMOSOMES & CANCER, 2002, 34 (01) :58-68
[19]   von Hippel-Lindau disease [J].
Lonser, RR ;
Glenn, GM ;
Walther, M ;
Chew, EY ;
Libutti, SK ;
Linehan, WM ;
Oldfield, EH .
LANCET, 2003, 361 (9374) :2059-2067
[20]   VONHIPPEL-LINDAU DISEASE - A GENETIC-STUDY [J].
MAHER, ER ;
ISELIUS, L ;
YATES, JRW ;
LITTLER, M ;
BENJAMIN, C ;
HARRIS, R ;
SAMPSON, J ;
WILLIAMS, A ;
FERGUSONSMITH, MA ;
MORTON, N .
JOURNAL OF MEDICAL GENETICS, 1991, 28 (07) :443-447
1234