A Cerebellar Tumor-to-Tumor Metastasis in a Patient With Von Hippel-Lindau Disease

被引：0

作者：

Wang, Tengfei ^{[1
]}

Liu, Lina ^{[1
]}

Rampisela, Debby ^{[1
]}

Dong, Xiuhua ^{[1
]}

Keith, Kristin Alexndria ^{[2
]}

Benardete, Ethan A. ^{[2
]}

Shan, Frank Y. ^{[1
,2
]}

机构：

[1] Baylor Scott & White Hlth, Dept Pathol, Temple, TX USA

[2] Baylor Scott & White Hlth, Dept Neurosurg, Temple, TX USA

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2024年 / 32卷 / 05期

关键词：

Tumor-to-tumor metastasis; von Hippel-Lindau disease; ccRCC; hemangioblastoma; molecular-determined anatomic preference; RENAL-CELL-CARCINOMA; SUPPRESSOR GENE; HEMANGIOBLASTOMA; EXPRESSION; HYPOXIA; CHROMOSOME-3; LIGAND; RARE;

D O I：

10.1097/PAI.0000000000001197

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Tumor-to-tumor metastasis in the central nerve system is uncommon in our routine practice. Most reports include metastatic breast cancer into meningioma. Here we report a metastatic clear cell renal cell carcinoma (ccRCC) into a cerebellar hemangioblastoma in a patient with von Hippel-Lindau (VHL) disease. Imaging cannot distinguish metastatic ccRCC from primary cerebellar hemangioblastoma. Immuno-molecular studies are proven to be diagnostic. We also reviewed previously documented tumor-to-tumor metastasis of ccRCC to cerebellar hemangioblastoma in VHL disease. Lastly, we discussed potential mechanisms involved in the metastasis of ccRCC to hemangioblastoma in the cerebellum in patients with VHL.

引用

页码：244 / 248

页数：5

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