Up-regulation of calcitonin gene-related peptide in trigeminal ganglion following chronic exposure to paracetamol in a CSD migraine animal model

被引:28
作者
Yisarakun, Waranurin [1 ]
Chantong, Chattraporn [1 ]
Supornsilpchai, Weera [2 ]
Thongtan, Thananya [3 ]
Srikiatkhachorn, Anan [4 ]
Reuangwechvorachai, Preecha [1 ]
Maneesri-le Grand, Supang [1 ]
机构
[1] Chulalongkorn Univ, Fac Med, Dept Pathol, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Fac Dent, Dept Physiol, Bangkok 10330, Thailand
[3] Chulalongkorn Univ, Fac Med, Dept Biochem, Bangkok 10330, Thailand
[4] Chulalongkorn Univ, Fac Med, Dept Physiol, Bangkok 10330, Thailand
关键词
Paracetamol; Cortical spreading depression; Calcitonin gene-related peptide; Trigeminal ganglion; CORTICAL SPREADING DEPRESSION; NITRIC-OXIDE SYNTHESIS; ACTIVITY-MODIFYING PROTEIN-1; SUBSTANCE-P; TRIGEMINOVASCULAR SYSTEM; 5-HT2A RECEPTOR; MESSENGER-RNA; EXPRESSION; CGRP; ACETAMINOPHEN;
D O I
10.1016/j.npep.2015.03.008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Previously, our group has demonstrated that chronic paracetamol (APAP) treatment induces alterations to the trigeminovascular nociceptive system in the cortical spreading depression (CSD) migraine animal model. The calcitonin gene related peptide (CGRP) is a key neuropeptide involved in the activation of the trigeminovascular nociceptive system. Therefore, this study examined the expression levels of CGRP in the trigeminal ganglion (TG) after chronic APAP exposure (0, 15, and 30 days) using a CSD model. Rats were divided into control, CSD only, APAP only and APAP treatment with CSD groups. A single injection (i.p.) of APAP (200 mg/kg body weight) was given to the 0-day APAP-treated groups, while the other APAP-treated groups received daily injections for 15 and 30 days. CSD was induced by the topical application of KCl to the parietal cortex. The protein expression of CGRP in the TG was evaluated by immunohistochemistry, and the CGRP mRNA level was investigated by real-time quantitative reverse transcription polymerase chain reaction. The results revealed that the induction of CSD significantly increased the level of CGRP protein but had no effect on CGRP mRNA level. Pretreatment with APAP 1 hour before CSD activation significantly reduced CGRP expression induced by CSD. In contrast, chronic treatment with APAP (15 and 30 days) significantly enhanced CGRP expression in both protein and mRNA levels when compared with the control groups. In combination with CSD, the expression of CGRP further increased in the animal with 30 day treatment. These findings indicate that chronic treatment with APAP induces an increase of CGRP expression in the TG. This alteration may be associated with the increased trigeminovascular nociception observed in our previous studies. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:9 / 16
页数:8
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