Superficial Atypical Lipomatous Tumor With Pleomorphic Features: Case Report and Discussion of the Literature

被引:0
作者
Adeuyan, Oluwaseyi [1 ]
Gordon, Emily R. [1 ]
Lapolla, Brigit A. [2 ]
Schreidah, Celine M. [1 ]
Jobanputra, Vaidehi [3 ]
Gru, Alejandro A. [2 ]
Geskin, Larisa J. [1 ,2 ]
机构
[1] Columbia Univ, Vagelos Coll Phys & Surg, New York, NY USA
[2] Columbia Univ, Dept Dermatol, Irving Med Ctr, 161 Ft Washington Ave,12th Floor, New York, NY 10032 USA
[3] Columbia Univ, Irving Med Ctr, Dept Pathol & Cell Biol, New York, NY USA
关键词
atypical lipomatous tumor; well-differentiated liposarcoma; dedifferentiated liposarcoma; pleomorphic liposarcoma; spindle cell lipoma; pleomorphic lipoma; atypical spindle cell/pleomorphic lipomatous tumor;
D O I
10.1097/DAD.0000000000002745
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Among liposarcomas, well-differentiated liposarcoma and dedifferentiated liposarcoma are the most common. The majority of these tumors are found in deep retroperitoneum or extremities. When found outside the retroperitoneum, these adipose-derived tumors are known as atypical lipomatous tumors (ALT). Superficial ALT are particularly rare; thus, little is known about their clinical presentation, genomic status, and management. Here, we present the case of a 54-year-old man with an intermittently bothersome, slowly growing mass on his left upper back for over 2 years, which was incidentally diagnosed as ALT. This patient's ALT, however, showed a profound degree of pleomorphism with MDM2 and control centromere 12 (CEP12) coamplification and negative CD34 and S100 and RB1 expression, unlike most other ALT described in the literature. This case report details the diagnostic workup and histopathological findings for adipose tumors and summarizes the different subtypes, including atypical spindle cell/pleomorphic lipomatous tumor, pleomorphic liposarcoma, and spindle cell/pleomorphic lipoma, with brief discussion on management.
引用
收藏
页码:509 / 511
页数:3
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