Efficacy and safety of percutaneous ultrasound-guided thermal ablation in the treatment of cervical metastatic lymph nodes from papillary thyroid carcinoma

被引:0
|
作者
Zhang, Shen [1 ,2 ,3 ]
Liu, Yunyun [2 ,3 ]
Zhou, Bangguo [2 ,3 ]
Xu, Huixiong [4 ]
机构
[1] Nanjing Med Univ, Shanghai Peoples Hosp 10, Ctr Minimally Invas Treatment Tumor, Dept Med Ultrasound, Shanghai, Peoples R China
[2] Tongji Univ, Shanghai Peoples Hosp 10, Ultrasound Res & Educ Inst,Clin Res Ctr Intervent, Dept Med Ultrasound,Sch Med, Shanghai, Peoples R China
[3] Shanghai Engn Res Ctr Ultrasound Diag & Treatmen, Shanghai, Peoples R China
[4] Fudan Univ, Inst Ultrasound Med & Engn, Zhongshan Hosp, Dept Ultrasound, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
Ultrasound; thermal ablation; papillary thyroid carcinoma; lymph nodes; RADIOFREQUENCY ABLATION; MICROWAVE ABLATION; RECURRENT; CANCER; SURVEILLANCE; ASSOCIATION; MANAGEMENT; LASER;
D O I
10.3233/CH-231998
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: To evaluate the efficacy and safety of percutaneous ultrasound-guided thermal ablation in the treatment of cervical metastatic lymph nodes (LNs) from papillary thyroid carcinoma (PTC). MATERIALS AND METHODS: A total of 77 patients with 79 LNs ablated by microwave ablation (MWA) or radiofrequency ablation (RFA) between September 2018 and October 2022 were enrolled in this study. After treatment, patients were followed up with measurement of diameters of LNs and serum thyroglobulin (s-Tg) at 1, 3, 6, and 12 months and annually thereafter. The paired t-test was used to compare the changes of s-Tg level, diameters of LNs before and after ablation. RESULTS: There were no serious complications related to ablation while one case of incomplete ablation in MWA was found during follow-up. The mean longest and shortest diameter of the ablated LNs reduced from 11.6 +/- 4.3mm to 5.0 +/- 4.1mm (p < 0.001), and from 6.1 +/- 1.9mm to 3.0 +/- 2.5mm (p < 0.001) at the last follow-up visit. Besides, the final volume reduction rate (VRR) was 61.8 +/- 56.4% (range, -67.0 -100%). The complete disappearance rate was 46.8%, but there were 4 (5.1%) LNs becoming bigger than before. The average s-Tg level was 9.2 +/- 26.6 ng/mL, a data significantly decreased to 3.7 +/- 7.0 ng/mL at the last follow-up, but no statistical difference was shown. CONCLUSION: Thermal ablation is an effective and safe modality for the treatment of metastatic LNs from PTC.
引用
收藏
页码:77 / 87
页数:11
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