The global burden of fracture-related infection: can we do better?

被引：30

作者：

Metsemakers, Willem-Jan ^{[1
,3
]}

Moriarty, T. Fintan ^{[4
,5
]}

Morgenstern, Mario ^{[5
]}

Marais, Leonard ^{[6
]}

Onsea, Jolien ^{[1
,3
]}

O'Toole, Robert, V ^{[7
]}

Depypere, Melissa ^{[2
]}

Obremskey, William ^{[8
]}

Verhofstad, Michael H. J.

McNally, Martin ^{[9
]}

Morshed, Saam ^{[10
,11
]}

Wouthuyzen-Bakker, Marjan ^{[12
]}

Zalavras, Charalampos ^{[13
]}

机构：

[1] Univ Hosp Leuven, Dept Trauma Surg, B-3000 Leuven, Belgium

[2] Univ Hosp Leuven, Dept Lab Med, Leuven, Belgium

[3] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium

[4] AO Res Inst Davos, Davos, Switzerland

[5] Univ Hosp Basel, Ctr Musculoskeletal Infect, Dept Orthopaed & Trauma Surg, Basel, Switzerland

[6] Univ KwaZulu Natal, Sch Clin Med, Dept Ophthalmol, Durban, South Africa

[7] Univ Maryland, Sch Med, R Adams Cowley Shock Trauma Ctr, Dept Orthopaed, Baltimore, MD USA

[8] Vanderbilt Univ, Med Ctr, Dept Orthopaed Surg & Rehabil, Nashville, TN USA

[9] Univ Med Ctr Rotterdam, Dept Surg, Trauma Res Unit, Erasmus MC, Rotterdam, Netherlands

[10] Univ Calif San Francisco, Dept Orthopaed Surg, San Francisco, CA USA

[11] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[12] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol & Infect Prevent, Groningen, Netherlands

[13] Univ Southern Calif, Keck Sch Med, Dept Orthopaed Surg, Los Angeles, CA USA

来源：

LANCET INFECTIOUS DISEASES | 2024年 / 24卷 / 06期

关键词：

SURGICAL SITE INFECTION; OPEN TIBIA FRACTURES; ANTIBIOTIC-PROPHYLAXIS; BONE; PREVENTION; CARE; MANAGEMENT; TRIAL; OSTEOMYELITIS; COMPLICATIONS;

D O I：

10.1016/S1473-3099(23)00503-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Fracture-related infection is a major complication related to musculoskeletal injuries that not only has important clinical consequences, but also a substantial socioeconomic impact. Although fracture-related infection is one of the oldest disease entities known to mankind, it has only recently been defined and, therefore, its global burden is still largely unknown. In this Personal View, we describe the origin of the term fracture-related infection, present the available data on its global impact, and discuss important aspects regarding its prevention and management that could lead to improved outcomes in both high-resource and low-resource settings. We also highlight the need for health-care systems to be adequately compensated for the high cost of human resources (trained staff) and wellequipped facilities required to adequately care for these complex patients. Our aim is to increase awareness among clinicians and policy makers that fracture-related infection is a disease entity that deserves prioritisation in terms of research, with the goal to standardise treatment and improve patient outcomes on a global scale.

引用

页码：e386 / e393

页数：8

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