The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair

被引：12

作者：

Cai, Junrong ^{[1
]}

Quan, Yuping ^{[1
]}

Zhu, Shaowei ^{[1
]}

Lin, Jiayan ^{[1
]}

Zhang, Qian ^{[1
]}

Liu, Juzi ^{[1
]}

Liang, Zhuokai ^{[1
]}

Liao, Yunjun ^{[1
]}

Jiang, Wenqing

He, Yufei ^{[1
]}

Su, Ting ^{[1
]}

Lu, Feng ^{[1
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Plast & Cosmet Surg, 1838 Guangzhou North Rd, Guangzhou 510515, Guangdong, Peoples R China

来源：

CELL METABOLISM | 2024年 / 36卷 / 06期

基金：

中国国家自然科学基金;

关键词：

FAT; ADIPOCYTES; CELLS; ENDOCRINE;

D O I：

10.1016/j.cmet.2024.05.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adipocytes in dermis are considered to be important participants in skin repair and regeneration, but the role of subcutaneous white adipose tissue (sWAT) in skin repair is poorly understood. Here, we revealed the dynamic changes of sWAT during wound healing process. Lineage -tracing mouse studies revealed that sWAT would enter into the large wound bed and participate in the formation of granulation tissue. Moreover, sWAT undergoes beiging after skin injury. Inhibition of sWAT beiging by genetically silencing PRDM16, a key regulator to beiging, hindered wound healing process. The transcriptomics results suggested that beige adipocytes in sWAT abundantly express neuregulin 4 (NRG4), which regulated macrophage polarization and the function of myofibroblasts. In diabetic wounds, the beiging of sWAT was significantly suppressed. Thus, adipocytes from sWAT regulate multiple aspects of repair and may be therapeutic for inflammatory diseases and defective wound healing associated with aging and diabetes.

引用

页码：1287 / 1301.e7

页数：23

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