In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections

被引：0

作者：

Reidenberg, Bruce E. ^{[1
]}

Jenkins, Stephen G. ^{[2
,3
]}

Crandon, Jared L. ^{[4
]}

Hurlburt, Elizabeth ^{[4
]}

Tan, Xing ^{[4
]}

Rhomberg, Paul R. ^{[5
]}

Arends, S. J. Ryan ^{[5
]}

Pfaffle, Antony ^{[4
]}

机构：

[1] Weill Cornell Med, Dept Pharmacol, New York, NY USA

[2] Weill Cornell Med, Dept Med, Div Infect Dis, New York, NY USA

[3] Weill Cornell Med, Dept Pathol & Lab Med, New York, NY USA

[4] CorMedix Inc, Berkeley Hts, NJ 07922 USA

[5] JMI Labs, Element Iowa City, North Liberty, IA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2024年 / 68卷 / 07期

关键词：

taurolidine; Candida auris; catheter-related bloodstream infection; CLABSI; UNITED-STATES;

D O I：

10.1128/aac.00381-24

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates. Taurolidine was highly active with a MIC50/MIC90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of >= 13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.

引用

页数：5

共 20 条

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