Risk factors of post-intubation hypotension in severe pneumonia patients

Post-intubation hypotension (PIH) was one of the serious complications after Endotracheal intubation (ETI) in Severe pneumonia (SP) patients. The risk factors of PIH were investigated in SP patients to provide a theoretical basis of early intervention. This was a retrospective study wherein 420 SP patients undergone ETI from December 2019 to December 2022 were selected as the study subjects. Patients were divided into the hypotension and normal blood pressure groups based on the blood pressures recorded after intubation. Two groups were compared for the general data and various physicochemical indicators before the intubation. The independent risk factors of hypotension after tracheal intubation were explored in SP patients through univariate and multivariate logistic regression. PIH was developed in 170 (40.47%) SP patients. Univariate logistic regression analysis exhibited that age (Odd Ratio (OR) = 1.021, p = 0.001), weight (OR = 0.976, p = 0.015), inducer usage before intubation (OR = 1.221, p < 0.001), chronic obstructive pulmonary disease (OR = 1.768, p = 0.013), sepsis (OR = 1.870, p = 0.006), and hyperelastic acidemia (OR = 1.665, p = 0.012) were associated with PIH. Multivariate logistic regression analysis indicated that age (OR = 1.015, p = 0.033), weight (OR = 0.974, p = 0.012), inducer usage before intubation (OR = 1.228, p < 0.001), chronic obstructive pulmonary disease (OR = 1.660, p = 0.037), sepsis (OR = 1.733, p = 0.035), and hyperelastic acidemia (OR = 1.679, p = 0.018) were the independent risk factors of PIH. The study demonstrated that SP patients were prone to PIH with advanced age, low body weight, inducer usage before intubation, increased lactic acid levels before intubation, and high risk factors of chronic obstructive pulmonary disease (COPD) or sepsis. The findings had potential of advanced patient care, and refined medical practices, and could stimulate further investigations in the field.