Enhanced drug resistance suppression by serum-stable micelles from multi-arm amphiphilic block copolymers and tocopheryl polyethylene glycol 1000 succinate

被引：0
作者：
He, Lei [1 ,2 ,3 ]
Jiang, Cheng [2 ,3 ]
Ren, Jing [4 ]
Pan, Xiaoling [2 ,3 ]
Qiu, Zhiwen [2 ,3 ]
Xia, Yening [2 ,3 ]
Wang, Tian [1 ,2 ,3 ]
Guo, Jiahao [1 ,2 ,3 ]
Li, Junfang [4 ]
Li, Wei [1 ,2 ,3 ]
机构：
[1] Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, Shanghai 200093, Peoples R China
[2] Naval Med Univ, Dept Nanomed, Shanghai 200433, Peoples R China
[3] Naval Med Univ, Shanghai Key Lab Cell Engn, Shanghai 200433, Peoples R China
[4] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China
来源：
NANOMEDICINE | 2024年 / 19卷 / 14期
基金：
中国国家自然科学基金;
关键词：
drug-resistant cells; drug delivery; micelle; multi-arm polymer; serum stability; POLYMERIC MICELLES; IN-VITRO; NANOPARTICLES; INHIBITION; MDR1; TPGS;
D O I：
10.1080/17435889.2024.2347197
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To develop a robust drug-delivery system using multi-arm amphiphilic block copolymers for enhanced efficacy in cancer therapy. Materials & methods: Two series of amphiphilic polymer micelles, PEG-b-PCLm and PEG-b-PCLm/TPGS, were synthesized. Doxorubicin (DOX) loading into the micelles was achieved via solvent dialysis. Results: The micelles displayed excellent biocompatibility, narrow size distribution, and uniform morphology. DOX-loaded micelles exhibited enhanced antitumor efficacy and increased drug accumulation at tumor sites compared with free DOX. Additionally, 4A-PEG(47)-b-PCL21/TPGS micelles effectively suppressed drug-resistant MCF-7/ADR cells. Conclusion: This study introduces a novel micelle formulation with exceptional serum stability and efficacy against drug resistance, promising for cancer therapy. It highlights innovative strategies for refining clinical translation and ensuring sustained efficacy and safety in vivo.
引用
收藏
页码：1297 / 1311
页数：15
相关论文
共 35 条
  • [1] Anticancer chemotherapy in teenagers and young adults: managing long term side effects
    Ahmad, Saif S.
    Reinius, Marika A. V.
    Hatcher, Helen M.
    Ajithkumar, Thankamma V.
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2016, 354 : i4567
  • [2] Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp
    Alfarouk, Khalid O.
    Stock, Christian-Martin
    Taylor, Sophie
    Walsh, Megan
    Muddathir, Abdel Khalig
    Verduzco, Daniel
    Bashir, Adil H. H.
    Mohammed, Osama Y.
    Elhassan, Gamal O.
    Harguindey, Salvador
    Reshkin, Stephan J.
    Ibrahim, Muntaser E.
    Rauch, Cyril
    [J]. CANCER CELL INTERNATIONAL, 2015, 15
  • [3] Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion
    Batrakova, EV
    Li, S
    Elmquist, WF
    Miller, DW
    Alakhov, VY
    Kabanov, AV
    [J]. BRITISH JOURNAL OF CANCER, 2001, 85 (12) : 1987 - 1997
  • [4] Paclitaxel-loaded PCL-TPGS nanoparticles: In vitro and in vivo performance compared with Abraxane®
    Bernabeu, Ezequiel
    Helguera, Gustavo
    Legaspi, Maria J.
    Gonzalez, Lorena
    Hocht, Christian
    Taira, Carlos
    Chiappetta, Diego A.
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2014, 113 : 43 - 50
  • [5] Drug-excipient interactions by Vitamin E-TPGS:: in vitro studies on inhibition of P-glycoprotein and colonic drug absorption
    Bittner, B.
    Gonzalez, R. C. Bravo
    Bohrmann, B.
    Kuentz, M.
    Huwyler, J.
    [J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2008, 18 (02) : 145 - 148
  • [6] Pharmacokinetic resistance to imatinib mesylate - Role of the ABC drug pumps ABCG2 (BCRP) and ABCB1 (MDR1) in the oral bioavailability of imatinib
    Burger, H
    Nooter, K
    [J]. CELL CYCLE, 2004, 3 (12) : 1502 - 1505
  • [7] Timeline - Chemotherapy and the war on cancer
    Chabner, BA
    Roberts, TG
    [J]. NATURE REVIEWS CANCER, 2005, 5 (01) : 65 - 72
  • [8] Target-responsive DNA/RNA nanomaterials for microRNA sensing and inhibition: The jack-of-all-trades in cancer nanotheranostics?
    Conde, Joao
    Edelman, Elazer R.
    Artzi, Natalie
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2015, 81 : 169 - 183
  • [9] A History of Cancer Chemotherapy
    DeVita, Vincent T., Jr.
    Chu, Edward
    [J]. CANCER RESEARCH, 2008, 68 (21) : 8643 - 8653
  • [10] siRNA nanocarriers based on methacrylic acid copolymers
    Felber, Arnaud E.
    Castagner, Bastien
    Elsabahy, Mahmoud
    Deleavey, Glen F.
    Damha, Masad J.
    Leroux, Jean-Christophe
    [J]. JOURNAL OF CONTROLLED RELEASE, 2011, 152 (01) : 159 - 167
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