Real-world effectiveness and safety of bimekizumab for hidradenitis suppurativa: An ambispective observational study

被引：2

作者：

Mansilla-Polo, Miguel ^{[1
,2
]}

Pons-Benavent, Marti ^{[3
]}

Fernandez-Crehuet, Pablo ^{[4
]}

Vilarrasa, Eva ^{[5
]}

Albanell-Fernandez, Cristina ^{[6
]}

Morales-Tedone, Enrico ^{[6
]}

Rausell-Felix, Francisca ^{[6
]}

Alcala-Garcia, Rebeca ^{[7
]}

Matellanes-Palacios, Maria ^{[7
]}

Martin-Ezquerra, Gemma ^{[8
]}

Alfageme, Fernando ^{[9
]}

Ciudad-Blanco, Cristina ^{[10
]}

Lopez-Villaescusa, Maria Teresa ^{[11
]}

Garbayo-Salmons, Patricia ^{[12
]}

Martorell, Antonio ^{[13
]}

Escutia-Munoz, Begona ^{[1
,2
]}

Navarro-Blanco, Fernando ^{[1
,2
]}

Martin-Torregrosa, Daniel ^{[1
,2
]}

Cuenca-Barrales, Carlos ^{[14
]}

Molina-Leyva, Alejandro ^{[14
]}

Botella-Estrada, Rafael ^{[1
,2
,15
]}

机构：

[1] Hosp Univ & Politecn La Fe, Dept Dermatol, 106 Ave Fernando Abril Martorell, Valencia 46026, Spain

[2] Inst Invest Sanitaria IIS La Fe, Valencia, Spain

[3] Hosp Virgen Lirios, Dept Dermatol, Alicante, Spain

[4] Hosp Reina Sofia, Dept Dermatol, Cordoba, Spain

[5] Hosp Santa Creu St Pau, Dept Dermatol, Barcelona, Spain

[6] Hosp Clin Univ, Dept Dermatol, Valencia, Spain

[7] Hosp Sagunto, Dept Dermatol, Valencia, Spain

[8] Hosp Mar, Dept Dermatol, Barcelona, Spain

[9] Hosp Univ Puerta Hierro, Dept Dermatol, Madrid, Spain

[10] Hosp Univ Gregorio Maranon, Dept Dermatol, Madrid, Spain

[11] Complejo Hosp Univ Albacete, Dept Dermatol, Albacete, Spain

[12] Hosp Parc Tauli Sabadell, Dept Dermatol, Barcelona, Spain

[13] Hosp Manises, Dept Dermatol, Valencia, Spain

[14] Hosp Univ Virgen Nieves, Dept Dermatol, Granada, Spain

[15] Univ Valencia, Fac Med, Valencia, Spain

来源：

AUSTRALASIAN JOURNAL OF DERMATOLOGY | 2024年 / 65卷 / 07期

关键词：

bimekizumab; biologic therapy; effectiveness; hidradenitis suppurativa; safety;

D O I：

10.1111/ajd.14339

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In this original research, we present the results in terms of effectiveness and safety of bimekizumab for hidradenitis suppurativa in real clinical practice. Results indicated significant improvement in all activity scores and patient-reported outcomes at week 16, including a notable decrease in mean IHS4 from 27.1 to 15.6 (p < 0.001), HS-PGA from 5.1 to 3.2 (p < 0.001), VAS pain from 8.3 to 4.7 (p < 0.001) and DLQI from 21.6 to 12.6 (p < 0.001). Bimekizumab, administered every 2 or 4 weeks, was well-tolerated with no discontinuations and no new safety concerns identified. These findings corroborate the drug's effectiveness and favourable safety profile observed in phase 3 clinical trials, supporting its use in real-world clinical practice for treating HS.

引用

页码：e198 / e202

页数：5

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