Advanced microfluidic devices for fabricating multi-structural hydrogel microsphere

Hydrogel microspheres are a novel functionalmaterial, arousingmuch attention in various fields. Microfluidics, a technology that controls and manipulates fluids at themicron scale, has emerged as a promising method for fabricating hydrogel microspheres due to its ability to generate uniform microspheres with controlled geometry. With the development of microfluidic devices, more complicated hydrogel microspheres withmultiple structures canbe constructed. This reviewpresents anoverviewof advances inmicrofluidics for designing and engineering hydrogel microspheres. It starts with an introduction to the features of hydrogelmicrospheres andmicrofluidic techniques, followed by a discussion of material selection for fabricating microfluidic devices. Then the progress of microfluidic devices for single-component and composite hydrogel microspheres is described, and themethod for optimizing microfluidic devices is also given. Finally, this review discusses the key research directions and applications of microfluidics for hydrogel microsphere in the future.