Obsessive -compulsive disorder;
Transcranial direct current stimulation;
EEG microstate;
Neuromodulation;
RESTING-STATE NETWORKS;
BRAIN NETWORKS;
DISORDER;
CONNECTIVITY;
SYSTEMS;
ATTENTION;
CORTEX;
OCD;
D O I:
10.1016/j.jpsychires.2024.06.034
中图分类号:
R749 [精神病学];
学科分类号:
100205 ;
摘要:
Background: Transcranial direct current stimulation (tDCS) is a safe, accessible, and promising therapeutic approach for obsessive-compulsive disorder (OCD). Aims: This study aimed to evaluate the effect of tDCS on electroencephalography (EEG) microstates and identify potential biomarkers to predict efficacy. Methods: A total of 24 individuals diagnosed with OCD underwent ten sessions of tDCS targeting the orbitofrontal cortex, while 27 healthy individuals were included as controls. Microstates A, B, C, and D were extracted before and after tDCS. A comparative analysis of microstate metrics was performed between the OCD and the healthy control groups, as well as within the OCD group before and after tDCS. Multiple linear regression analysis was performed to identify potential biomarkers of tDCS. Results: Comparison to healthy controls, the OCD group exhibited a significantly reduced duration of microstate A and increased occurrence of microstate D. The transition between microstates A and C was significantly different between patients with OCD and healthy controls and was no longer observed following tDCS. Multiple linear regression analysis revealed that the duration of microstate C was associated with an improvement OCD symptom after tDCS. Conclusions: The results revealed an aberrant large-scale EEG brain network that could be modulated by tDCS. In particular, the duration of EEG microstate C may be a neurophysiological characteristic associated with the therapeutic effects of tDCS on OCD.
机构:
Univ Lyon 1, Ctr Hosp Vinatier, EA 4615, F-69003 Bron, FranceUniv Lyon 1, Ctr Hosp Vinatier, EA 4615, F-69003 Bron, France
Bation, Remy
Poulet, Emmanuel
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Univ Lyon 1, Ctr Hosp Vinatier, EA 4615, F-69003 Bron, France
CHU Lyon, Groupement Hosp Edouard Herriot, Serv Psychiat Urgences, Lyon, FranceUniv Lyon 1, Ctr Hosp Vinatier, EA 4615, F-69003 Bron, France
Poulet, Emmanuel
Haesebaert, Frederic
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Univ Lyon 1, Ctr Hosp Vinatier, EA 4615, F-69003 Bron, FranceUniv Lyon 1, Ctr Hosp Vinatier, EA 4615, F-69003 Bron, France
Haesebaert, Frederic
Saoud, Mohamed
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机构:
Univ Lyon 1, Ctr Hosp Vinatier, EA 4615, F-69003 Bron, France
CHU Lyon, Hop Pierre Wertheimer Psychiat Adultes Consultat, Groupement Hosp Est, Lyon, FranceUniv Lyon 1, Ctr Hosp Vinatier, EA 4615, F-69003 Bron, France
Saoud, Mohamed
Brunelin, Jerome
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Univ Lyon 1, Ctr Hosp Vinatier, EA 4615, F-69003 Bron, FranceUniv Lyon 1, Ctr Hosp Vinatier, EA 4615, F-69003 Bron, France
机构:
Univ Claude Bernard Lyon 1, Lyon Neurosci Res Ctr, PSYR2 Team, CNRS,INSERM,UMR5292,U1028, Lyon, France
Ctr Hosp Vinatier, Bron, France
CHU Lyon, Wertheimer Neurol Hosp, Psychiat Unit, F-69500 Bron, FranceUniv Claude Bernard Lyon 1, Lyon Neurosci Res Ctr, PSYR2 Team, CNRS,INSERM,UMR5292,U1028, Lyon, France
Bation, Remy
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机构:
Mondino, Marine
Le Camus, Florent
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h-index: 0
机构:
Univ Claude Bernard Lyon 1, Lyon Neurosci Res Ctr, PSYR2 Team, CNRS,INSERM,UMR5292,U1028, Lyon, France
Ctr Hosp Vinatier, Bron, FranceUniv Claude Bernard Lyon 1, Lyon Neurosci Res Ctr, PSYR2 Team, CNRS,INSERM,UMR5292,U1028, Lyon, France
Le Camus, Florent
Saoud, Mohamed
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h-index: 0
机构:
Univ Claude Bernard Lyon 1, Lyon Neurosci Res Ctr, PSYR2 Team, CNRS,INSERM,UMR5292,U1028, Lyon, France
Ctr Hosp Vinatier, Bron, France
CHU Lyon, Wertheimer Neurol Hosp, Psychiat Unit, F-69500 Bron, FranceUniv Claude Bernard Lyon 1, Lyon Neurosci Res Ctr, PSYR2 Team, CNRS,INSERM,UMR5292,U1028, Lyon, France
Saoud, Mohamed
Brunelin, Jerome
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h-index: 0
机构:
Univ Claude Bernard Lyon 1, Lyon Neurosci Res Ctr, PSYR2 Team, CNRS,INSERM,UMR5292,U1028, Lyon, France
Ctr Hosp Vinatier, Bron, FranceUniv Claude Bernard Lyon 1, Lyon Neurosci Res Ctr, PSYR2 Team, CNRS,INSERM,UMR5292,U1028, Lyon, France
机构:
Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, RS, Brazil
Mendes Filho, Vauto A.
Cachoeira, Carolina T.
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Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, RS, Brazil
Cachoeira, Carolina T.
Dellai, Diego
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Hosp Clin Porto Alegre, Serv Psiquiat, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, RS, Brazil
Dellai, Diego
da Silva, Nathalia J.
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Hosp Clin Porto Alegre, Serv Psiquiat, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, RS, Brazil
da Silva, Nathalia J.
de Abreu, Paulo Belmonte
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Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, RS, Brazil
de Abreu, Paulo Belmonte
Lobato, Maria Ines R.
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Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, RS, Brazil
机构:
Dr Ismail Polyclin, Dept Psychiat, Dubai, U Arab Emirates
Natl Med Ctr, Dubai, U Arab EmiratesNatl Inst Mental Hlth & Neurosci, Dept Psychiat, Bengaluru 560029, Karnataka, India
Banwari, Girish
Tharayil, Harish M.
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机构:
Govt Med Coll, Dept Psychiat, Kozhikode, Kerala, IndiaNatl Inst Mental Hlth & Neurosci, Dept Psychiat, Bengaluru 560029, Karnataka, India
Tharayil, Harish M.
Karia, Sagar
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机构:
Lokmanya Tilak Municipal Med Coll & Gen Hosp, Dept Psychiat, Mumbai, Maharashtra, IndiaNatl Inst Mental Hlth & Neurosci, Dept Psychiat, Bengaluru 560029, Karnataka, India
机构:
Hop Univ Henri Mondor, AP HP, Serv Psychiat, F-94000 Creteil, France
Hop Albert Chenevier, 40 Rue Mesly, F-94000 Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Psychiat, F-94000 Creteil, France
Saba, Ghassen
Moukheiber, Albert
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Hop Univ Henri Mondor, AP HP, Serv Psychiat, F-94000 Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Psychiat, F-94000 Creteil, France
Moukheiber, Albert
Pelissolo, Antoine
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Hop Univ Henri Mondor, AP HP, Serv Psychiat, F-94000 Creteil, France
Univ Paris Est, Fac Med, F-94000 Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Psychiat, F-94000 Creteil, France