EEG microstates are associated with the improvement of obsessive-compulsive symptoms after transcranial direct current stimulation

被引:3
|
作者
Cheng, Jiayue [1 ]
Wang, Yang [1 ]
Tang, Yingying [1 ]
Lin, Liangjun [2 ]
Gao, Jian [1 ]
Wang, Zhen [1 ,3 ,4 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, 600 Wan Ping Nan Rd, Shanghai 200030, Peoples R China
[2] Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Suzhou 215004, Peoples R China
[3] Shanghai Jiao Tong Univ, Inst Psychol & Behav Sci, Shanghai, Peoples R China
[4] Shanghai Intelligent Psychol Evaluat & Intervent E, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
Obsessive -compulsive disorder; Transcranial direct current stimulation; EEG microstate; Neuromodulation; RESTING-STATE NETWORKS; BRAIN NETWORKS; DISORDER; CONNECTIVITY; SYSTEMS; ATTENTION; CORTEX; OCD;
D O I
10.1016/j.jpsychires.2024.06.034
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Transcranial direct current stimulation (tDCS) is a safe, accessible, and promising therapeutic approach for obsessive-compulsive disorder (OCD). Aims: This study aimed to evaluate the effect of tDCS on electroencephalography (EEG) microstates and identify potential biomarkers to predict efficacy. Methods: A total of 24 individuals diagnosed with OCD underwent ten sessions of tDCS targeting the orbitofrontal cortex, while 27 healthy individuals were included as controls. Microstates A, B, C, and D were extracted before and after tDCS. A comparative analysis of microstate metrics was performed between the OCD and the healthy control groups, as well as within the OCD group before and after tDCS. Multiple linear regression analysis was performed to identify potential biomarkers of tDCS. Results: Comparison to healthy controls, the OCD group exhibited a significantly reduced duration of microstate A and increased occurrence of microstate D. The transition between microstates A and C was significantly different between patients with OCD and healthy controls and was no longer observed following tDCS. Multiple linear regression analysis revealed that the duration of microstate C was associated with an improvement OCD symptom after tDCS. Conclusions: The results revealed an aberrant large-scale EEG brain network that could be modulated by tDCS. In particular, the duration of EEG microstate C may be a neurophysiological characteristic associated with the therapeutic effects of tDCS on OCD.
引用
收藏
页码:360 / 367
页数:8
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